Article

Pharmacokinetics of Selamectin in Dogs after Topical Application

Laboratoire de Pharmacologie-Toxicologie, INRA; Ecole Nationale Vétérinaire
Veterinary Research Communications (impact factor: 0.82). 06/2004; 28(5):407-413. DOI:10.1023/B:VERC.0000034993.87007.f8 pp.407-413

ABSTRACT Some pharmacokinetic parameters of selamectin were determined in male (n = 5) and female (n = 5) Beagle dogs following a topical application at a dose rate of 6 mg/kg. The plasma concentration versus time data for the drug were analysed using a one-compartment model. The maximum plasma concentrations of 12.725.13 ng/ml for males and 22.6511.95 ng/ml for females occurred around 5 days after administration. The area under the concentration–time curve (AUC) was 192.0863.85 ng.day/ml for males and 370.97146.87 ng.day/ml for females. The mean residence time was the same in males and females (12.55 days). This study reveals a sex-influence on the disposition of selamectin in the plasma of dogs, which implies that further information will be needed for correlation with efficacy studies in dogs.

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Keywords

5 days
 
concentration–time curve
 
disposition
 
females
 
males
 
maximum plasma concentrations
 
mean residence time
 
one-compartment model
 
pharmacokinetic parameters
 
time data
 
topical application