Article

Electroretinographic oscillatory potentials in diabetic retinopathy

People's Hospital, Beijing Medical University
Documenta Ophthalmologica (Impact Factor: 1.54). 05/1992; 81(2):173-179. DOI: 10.1007/BF00156006

ABSTRACT The oscillatory potentials of the electroretinogram in dark and light adaptation were evaluated by Fourier transform in 87 diabetics and 74 age-matched controls. The study consisted of four groups: normal control, no observable diabetic retinopathy, background diabetic retinopathy and proliferative diabetic retinopathy. A reduction in the amplitude of each oscillatory potential, the summed amplitudes, the area and the total power of the oscillatory potentials as well as delayed implicit time of each oscillatory potential peak in dark and light adaptation could be found in patients with background diabetic retinopathy and proliferative diabetic retinopathy. The amplitude of oscillatory potential 4 in dark adaptation and the total power of the oscillatory potentials in light adaptation seemed to be affected in patients with no observable diabetic retinopathy. The implicit time of oscillatory potential 2 in dark adaptation was valuable to distinguish between patients with no observable diabetic retinopathy and background diabetic retinopathy.

0 Bookmarks
 · 
35 Views
  • [Show abstract] [Hide abstract]
    ABSTRACT: Persons with type 1 diabetes show electrophysiological abnormalities of the visual system which are revealed by methods such as flash electroretinogram (FERG), oscillatory potentials (OPs), pattern electroretinogram (PERG), focal electroretinogram (focal ERG), visual evoked potentials (VEP) in basal condition and after photostress. This review reports the changes in electrophysiological responses of the different structures composing the visual system observed in persons with type 1 diabetes before the development of the overt clinical retinopathy. In persons with type 1 diabetes without retinopathy (IDD), the earlier abnormal electrophysiological responses are recorded from the innermost retinal layers and postretinal visual pathways, as suggested by impaired PERGs and delayed retinocortical time (RCT). These are observed in IDD persons with a disease duration shorter than 6 months. Further electrophysiological changes are recorded from the macula (abnormal focal ERG and VEP after photostress) in IDD persons with disease duration greater than 1 year. Additional electrophysiological changes are recorded from the middle and outer retinal layers (impaired FERG and OPs) in IDD persons with a disease duration greater than 10 years. All the electrophysiological tests show a greater degree of abnormal responses in persons with type 1 diabetes when a background retinopathy is present.
    Diabetes/Metabolism Research and Reviews 01/2001; 17(1):12-8. · 2.97 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: To explore the retinal functions in healthy volunteers during acute hypoxic exposure, applying a set of electrophysiological tests. Standard electroretinograms (ERGs) of the retina (rod-(scotopic) ERGs, cone-(photopic) ERGs, maximal responses and oscillatory potentials (OPs)) and 30-Hz flicker ERGs were recorded according to ISCEV (International Society of Clinical Electrophysiology of Vision) recommendations in 14 healthy volunteers during a 15-min exposure to a simulated altitude of 5500 m. The mean arterial oxygen saturation level was significantly reduced (P < 0.001) during the hypobaric challenge. It returned to the normal level very shortly after the end of the hypoxic exposure. No significant change in the latency or amplitude of the slow components of the ERG was found in any recording. The OPs of the ERG, however, revealed a significant decrease in amplitude during hypoxic exposure. Both OP1 and OP2 amplitudes were significantly different (P < 0.05) from the baseline values during hypoxia. Partial recovery of these waves occurred after termination of the hypoxia. These results appear to support the notion that the inner layers of the retina presumed to be the main source of the OPs, display the highest sensitivity towards circulatory and/or hypoxic challenges.
    Documenta Ophthalmologica 01/2007; 114(1):45-51. · 1.54 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: To investigate the effect of elevated plasma glucose levels on oscillatory potentials (OPs) in patients with diabetes mellitus. 15 patients with type 2 diabetes mellitus, with no ophthalmoscopically visible signs of diabetic retinopathy (NDR), were recruited, mean (SD) age 65.1 (10.91) years and duration 5.95 (4.95) years. Plasma glucose levels and OPs were recorded before, during and after a meal tolerance test (MTT), at times 0, 90 and 210 min. OPs were recorded following 5 min adaptation to a blue mesopic background (1.17 cd m(-2)), and elicited using a white 5 ms stimulus flickering at 5 Hz frequency over the blue background. Plasma glucose increased significantly from 0 to 90 min during the MTT. This corresponded with an increase in mean amplitude of OP1-4, and a significant increase in the summed amplitudes. Summed OP amplitudes were 14.52 microv and 18.38 microv at time 0 and 90 min respectively. Between times 90 and 210 min plasma glucose levels decreased significantly back to baseline. OP1 and OP2 amplitudes increased slightly and OP3 and OP4 amplitudes decreased markedly, resulting in a non-significant reduction of the summed amplitudes. No significant changes in latencies were seen. Summed OP amplitudes, which are known to reflect the efficiency of the retinal circulation, increased with elevated plasma glucose. This effect was not immediately reversible. Latencies appear not to be affected.
    Documenta Ophthalmologica 08/2004; 109(1):35-42. · 1.54 Impact Factor