Hydrogels are valuable materials for use in biosensors. They can be used for immobilization as well as for creating protecting
layers controlling diffusion and enhancing biocompatibility. Highly stable biosensors use hydrogels for entrapment of enzymes
on microelectrodes. The stability of enzymes in hydrogel membranes for biosensors can be enhanced by choosing the right microenvironment
using micro-hydrogels. The thermodynamic stability of the entrapped enzymes in micro-gels can be characterized via differential
scanning calorimetry (nano-DSC). Hydrogel-based biosensors were characterized by nano-DSC showing that hydrogel membranes
are excellent for creating long-term stable enzyme biosensors. Additionally, smart hydrogels can be used as stimuli responsive
materials enabling sensing as well as actuating performance.
[Show abstract][Hide abstract] ABSTRACT: The novelty of this study resides in the fabrication of stoichiometric and stress-reduced Si3N4/SiO2/Si3N4 triple-layer membrane sieves. The membrane sieves were designed to be very flat and thin, mechanically stress-reduced, and stable in their electrical and chemical properties. All insulating materials are deposited stoichiometrically by a low-pressure chemical vapor deposition system. The membranes with a thickness of 0.4 mu m have pores with a diameter of about 1 Am. The device is fabricated on a 6 '' silicon wafer with the semiconductor processes. We utilized the membrane sieves for plasma separations from human whole blood. To enhance the separation ability of blood plasma, an agarose gel matrix was attached to the membrane sieves. We could separate about 1 mu L of blood plasma from 5 mu L of human whole blood. Our device can be used in the cell-based biosensors or analysis systems in analytical chemistry.
[Show abstract][Hide abstract] ABSTRACT: Hydrogel materials consisting of water-swollen polymer networks exhibit a large number of specific properties highly attractive for a variety of optical biosensor applications. This properties profile embraces the aqueous swelling medium as the basis of biocompatibility, non-fouling behavior, and being not cell toxic, while providing high optical quality and transparency. The present review focuses on some of the most interesting aspects of surface-attached hydrogel films as active binding matrices in optical biosensors based on surface plasmon resonance and optical waveguide mode spectroscopy. In particular, the chemical nature, specific properties, and applications of such hydrogel surface architectures for highly sensitive affinity biosensors based on evanescent wave optics are discussed. The specific class of responsive hydrogel systems, which can change their physical state in response to externally applied stimuli, have found large interest as sophisticated materials that provide a complex behavior to hydrogel-based sensing devices.
[Show abstract][Hide abstract] ABSTRACT: Hydrogels have been employed as an emerging and promising tool in tissue engineering. They find application in the interdisciplinary field that applies the basic principles of biology and engineering and act as a substitute for conventional tissue engineering materials having improved and restored tissue function. This review article discusses the important characteristic properties of polymers used for the synthesis of hydrogels, which find application in tissue engineering. Furthermore, this article also reviews the recent advances and development in hydrogels used for corneal, cartilage, skin, bone and cardiac tissue for tissue engineering applications. This article highlights the future prospects and scope of hydrogels in tissue engineering.
Current Pharmaceutical Biotechnology 04/2015; 16(7). DOI:10.2174/138920101607150427111651 · 2.51 Impact Factor
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