Article

HLA-DQ polymorphism analyzed by sequential restriction endonuclease DNA digestion

The Wistar Institute of Anatomy and Biology; University of Pittsburgh School of Medicine; Pittsburgh Cancer Institute
Immunogenetics (impact factor: 2.93). 08/1986; 24(3):184-190. DOI:10.1007/BF00364747 pp.184-190

ABSTRACT A direct, physical correspondence between certain Pst I-generated genomic DNA fragments and Taq I-generated fragments, revealed with HLA-DQor -DQ

gene probes, has been demonstrated. As an immediate consequence, the nature of the DQ and DX hybridized genes contained in the fragments was established. Taq I-generated DQ allelic forms which associate with serologically defined DRl1 DR2, and DRw6 specificities were also proven to be sensu stricto splits of the Pst I-generated allelic form associated with all three DR specificities.

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Keywords

certain Pst I-generated genomic DNA fragments
 
DRw6 specificities
 
DX hybridized genes
 
physical correspondence
 
Pst I-generated allelic form
 
Taq I-generated fragments
 
three DR specificities
 

Massimo Trucco