Exposure to Environmental Endocrine Disruptors and Child Development

Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA.
JAMA Pediatrics (Impact Factor: 5.73). 06/2012; 166(6):E1-7. DOI: 10.1001/archpediatrics.2012.241
Source: PubMed


Exposure to exogenous chemicals can affect endocrine function at multiple sites and through numerous specific modes of action, which may have far-reaching effects on human health and development. Widespread human exposure to known or suspected endocrine disrupting chemicals (EDCs) has been documented in the United States and worldwide, as have trends for increased rates of endocrine-related diseases and disorders among children. While human epidemiology studies of exposure to EDCs and children's health remain extremely limited, a growing body of evidence shows that exposure to a number of chemicals commonly found in consumer goods, personal care products, food, drinking water, and other sources may adversely affect child development through altered endocrine function. This narrative review provides a brief introduction to several common EDCs (with a specific focus on persistent organic pollutants, phthalates, bisphenol A, and contemporary-use pesticides, which represent only a small number of all known or suspected EDCs), an overview of the state of the human evidence for adverse effects of EDCs on child development (fetal growth, early reproductive tract development, pubertal development, neurodevelopment, and obesity), guidance for health care providers based on current knowledge, and recommendations for future research.

1 Follower
26 Reads
  • Source
    • "Alterations in thyroid and steroid hormone function and activation of peroxisome proliferator-activated receptors might occur due to exposure to such endocrine disrupting chemicals (EDCs) influencing the adipocyte differentiation a'nd energy storage (Tang-Péronard et al., 2011; Thayer et al., 2012). Additionally, the presence of such synthetic chemicals in humans has been associated with elevated triglycerides and cholesterol, impaired fasting glucose and diabetes (Meeker, 2012; Tang-Péronard et al., 2011), factors that are all related to the body's natural weight control mechanisms potentially leading to obesity. Exposure to EDCs, such as BPA and phthalates, has already been linked to obesity in animal studies (Miyawaki et al., 2007; R.R. Newbold et al., 2007). "
    [Show abstract] [Hide abstract]
    ABSTRACT: Bisphenol A (BPA) and triclosan (TCS) were determined in urine of Belgian overweight and obese (n = 151) and lean (n = 43) individuals. After the first urine collection (0 M), obese patients started a diet program or have undergone bariatric surgery. Hereafter, three additional urine samples from obese patients were collected after 3 (3M), 6 (6M) and 12 (12 M) months. Both compounds were detected in N99% of the samples. BPA had median concentrations of 1.7 and 1.2 ng/mL in obese and lean groups, respectively, while TCS had median concentrations of 1.5 and 0.9 ng/mL in the obese and lean groups, respectively. The obese group had higher urinary concentrations (ng/mL) of BPA (p b 0.5), while no significant differences were found for TCS between the obese and lean groups. No time trends between the different collection moments were observed. The BPA concentrations in the obese group were negatively associated with age, while no gender difference or relationship with body mass index was observed. For TCS, no relationships with gender, BMI, or age were found. The temporal variability of BPA and TCS was assessed with calculation of the intra class correlation coefficient, Spearman rank correlation coefficients, and surrogate category analysis. We observed evidence that single spot urine samples might be predictive of exposure over a longer period of time. Dietary intakes of BPA and TCS did not differ significantly among the time points considered after obese individuals started losing weight (6 and 12 months). Multiple linear regression analyses after adjusting for age and weight loss revealed negative associations between urinary TCS and serumFT4 in the 0M and 3M female obese individuals and positive associations between urinary BPA and serum TSH in the lean group.
    Environment international 01/2015; 76(March 2015):98-105. DOI:10.1016/j.envint.2014.12.003 · 5.56 Impact Factor
    • "With the exponential growth of the chemical industry the use of synthetic chemicals become massive and therefore humans are continuously exposed to such substances [1] particularly in the indoor environment, where people tend to spend the vast majority of their life time. Hence, daily human exposure to these harmful chemicals has become, in the last decades, one of the major concerns to the public as well as the scientific community. "
    [Show abstract] [Hide abstract]
    ABSTRACT: Modern people spend a considerable time of their life indoors, whether at home, at the workplace or at school, or inside vehicles and public transportation, therefore exposure to a variety of contaminants present indoors is constant and profuse. These contaminants released from household products tend to accumulate and concentrate in dust which is thus considered as one of the main human exposure pathways to several chemicals either by inhalation or ingestion. Within this wide range of contaminants polybrominated diphenyl ethers and hexabromocyclododecanes are included. These two brominated flame retardants have been applied in a vast range of materials with the aim to inhibit or delay the combustion and prevent the fire progression thus increasing the available time for people to escape. The extensive usage granted them a ubiquitous presence in the indoor environment and also in humans. Due to their toxicity and their potential to bioaccumulate these flame retardants have been restricted or banned. However, their persistency in the environment and the increasing evidences of deleterious effects towards humans and wildlife renders the study of these contaminants a matter of great importance. In this review we gathered available information on the levels of PBDEs and HBCDs in indoor dust samples collected from different places and different regions around the world and discuss human exposure to these contaminants through dust.
    Current Organic Chemistry 10/2014; 18(17):2218 - 2230. DOI:10.2174/1385272819666140804231237 · 2.16 Impact Factor
  • Source
    • "The discrepancies observed with the first study could be explained by several hypotheses. Compared to the data from Rolschau [31] published in the 1970s, the higher percentage of battledore insertion observed in our study might be due to the increasing incidence of several factors that have been shown to affect pregnancy outcomes [32, 33], such as inadequate maternal environment (e.g., increasing maternal age of conception [34, 35], maternal smoking, and stress [36–38]), multiple births [37], pregnancies conceived with the aid of assisted reproductive technology [39], endocrine disruptors [40, 41], and specific environmental parameters (e.g., air pollution) [42]. "
    [Show abstract] [Hide abstract]
    ABSTRACT: Study question: To determine whether the umbilical cord insertion site of singleton pregnancies could be linked to the newborn birth weight at term and its individual growth potential achievement. Material and methods: A cohort study including 528 records of term neonates was performed. Each neonate was assessed for growth adjusted for gestational age according to the infant's growth potential using the AUDIPOG module. We considered two categories of umbilical cord insertions: central and peripheral. Intrauterine growth restriction was defined as birth weight below the 10th percentile. Statistical analysis was performed using Chi-square, Student's t test, Wilcoxon test, ANOVA, and logistic regression. Results: We observed a total of 343 centrally inserted cords versus 185 peripheral cords. There were twice as many smokers in the mothers of the peripheral category compared to the centrally inserted ones. More importantly, we demonstrated that only 17/343 (5.0%) of infants with central cord insertion were growth restricted, compared to 37/185 (20.0%) of the infants born with a peripheral insertion. Neonates with centrally inserted cord were significantly heavier. Conclusion: The umbilical cord insertion site of singleton pregnancies is associated with the newborn's birth weight at term and its individual growth potential achievement.
    BioMed Research International 05/2014; 2014:341251. DOI:10.1155/2014/341251 · 1.58 Impact Factor
Show more


26 Reads
Available from