Clear cell adenocarcinoma of a female urethra: A case report and review of the literature.

Department of Pathology, Farhat Hached Hospital, Sousse, Tunisia.
North American journal of medical sciences 11/2009; 1(6):321-3.
Source: PubMed

ABSTRACT Clear cell adenocarcinoma of the urethra is an extremely rare tumour. Its histogenetic derivation remains controversial.
We report a new case of clear cell adenocarcinoma of the proximal urethra in a 56-year-old woman who presented with grossly hematuria. Urethral cystoscopy revealed a tumour protruding from the posterior urethral wall at the bladder neck. Treatment consisted of urethrocystectomy with pelvic lymph node dissection. Histologically, the neoplasm consisted of clear cell adenocarcinoma of the urethra.
It appears that female urethral adenocarcinoma has more than one tissue of origin.

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    ABSTRACT: Clear cell carcinoma is an uncommon but distinct variant of urinary bladder carcinoma histologically resembling the neoplasm in the female genital tract. The histogenesis of this neoplasm is uncertain. The clinicopathologic and histologic features are suggestive of a mullerian origin in some tumors, while some believe it to be glandular differentiation of urothelium or a unique vesicular adenocarcinoma of non-mullerian origin.[1] We present a case of clear cell adenocarcinoma in a 74-year-old woman with review of literature along with its differential diagnosis.
    Urology Annals 09/2011; 3(3):151-4.

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