Article

Structuration nationale pour la prise en charge des lymphomes à petites (sprue réfractaire de type II) et grandes cellules associés à la maladie cœliaque

hôpital européen Georges-Pompidou Service d’hépatogastro-entérologie 20, rue Leblanc F-75015 Paris France; université Paris-Descartes Inserm U793, faculté Necker 156, rue de Vaugirard F-75015 Paris France
Oncologie (Impact Factor: 0.1). 05/2008; 10(6):421-424. DOI: 10.1007/s10269-008-0890-7

ABSTRACT RésuméLes lymphomes de bas et de haut grades sont des complications rares et graves de la maladie cœliaque. Les outils et critères
diagnostiques de ces lymphomes intestinaux sont récents, très spécialisés et insuffisamment diffusés. Il n’existe pas de traitement
efficace.

ButsHomogénéiser et diffuser les outils et critères diagnostiques, le suivi et la prise en charge thérapeutique.

Patients et méthodesCréation d’un réseau national constitué de 16 centres nationaux associés. L’expertise et les plateformes techniques de l’équipe
coordinatrice (études phénotypiques, histologiques, cytogénétiques et moléculaires) seront à la disposition de toutes les
équipes du réseau. Les données cliniques et biologiques des dossiers médicaux des patients seront centralisées et informatisées
dans une base de données et discutées au cours des réunions de concertation pluridisciplinaires nationales.

ConclusionLymphocœliaque devrait permettre une meilleure prise en charge diagnostique et thérapeutique des patients atteints de lymphomes
associés à la maladie cœliaque.

AbstractLow-grade and overt lymphomas are rare and severe complications of the celiac disease. The diagnostic techniques and criteria
to be used for these intestinal lymphomas are very specific; they have been developed recently and remain insufficiently known.
Efficient treatment does not exist.

AimsTo homogenize and make available for all the diagnostic techniques and criteria of these complications, their follow-up and
therapeutic management.

Patients and methodsOrganization of a national network that will include 16 national centres. The technical means, skills and experience of the
coordinating group (for phenotyping, histological, cytogenetic and molecular studies) will be available to all centres of
the network. Clinical and biological data of the patients will be centralized and recorded on computer medical files and discussed
during multidisciplinary committee meetings.

ConclusionThe “Lymphocœliaque” organization should improve the diagnosis and therapeutic management of celiac patients with lymphomas.

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