Article

Novel synthesis and cytotoxic activity of some chromeno[3,4-b]pyrrol-4(3H)-ones

Chemistry of Heterocyclic Compounds (impact factor: 0.73). 04/2012; 46(12):1514-1519. DOI:10.1007/s10593-011-0701-8 pp.1514-1519

ABSTRACT 1-Methylchromeno[3,4-b]pyrrol-4(3H)-one and 1-phenylchromeno[3,4-b]pyrrol-4(3H)-one derivatives have been synthesized by cyclization of amides obtained by condensing α-halo ketones with 3-amino-chromenones,
which show cytotoxic activity against lung, colon, and breast cancer cell lines.

Keywordsbenzopyrones–halo ketones–chromeno[3,4-b]pyrrol-4(3H)-ones–cytotoxic agents

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Keywords

1-phenylchromeno[3,4-b]pyrrol-4(3H)-one derivatives
 
breast cancer cell lines
 
colon
 
condensing α-halo ketones
 
show cytotoxic activity
 

S. S. Soman