Article

Xenobiotic-metabolizing enzymes as autoantigens in human autoimmune disorders

Clinical Reviews in Allergy & Immunology (impact factor: 3.68). 04/2012; 18(2):215-239. DOI:10.1385/CRIAI:18:2:215 pp.215-239

ABSTRACT Several diseases are characterized by the presence of autoantibodies directed against either CYP or xenobiotic-metabolizing
enzymes. They may be induced by toxic or idiopathic event. Very little is known about the mechanism of their triggering. When
a toxic compound was identified, the metabolic part was quite well-characterized and variations of metabolism could be a risk
factor in the development of the disease (e.g., dihydralazine-induced hepatitis). But in all the cases the abnormal immunological
response is not understood, although it seems clear that the autoantibodies are not by themselves responsible for the disease.

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Keywords

autoantibodies
 
clear
 
dihydralazine-induced hepatitis
 
diseases
 
idiopathic event
 
metabolic part
 
toxic
 
toxic compound