Evolution of migraine-associated symptoms in menstrually related migraine following symptomatic treatment with almotriptan

Abstract

In addition to headache, migraine is characterized by a series of symptoms that negatively affects the quality of life of
patients. Generally, these are represented by nausea, vomiting, photophobia, phonophobia and osmophobia, with a cumulative
percentage of the onset in about 90% of the patients. From this point of view, menstrually related migraine—a particularly
difficult-to-treat form of primary headache—is no different from other forms of migraine. Symptomatic treatment should therefore
be evaluated not only in terms of headache relief, but also by considering its effect on these migraine-associated symptoms
(MAS). Starting from the data collected in a recently completed multicentre, randomized, double-blind, placebo-controlled,
cross-over study with almotriptan in menstrually related migraine, an analysis of the effect of this drug on the evolution
of MAS was performed. Data suggest that almotriptan shows excellent efficacy on MAS in comparison to the placebo, with a significant
reduction in the percentages of suffering patients over a 2-h period of time.

KeywordsAcute treatment–Almotriptan–Menstrual migraine–Migraine-associated symptoms