Article

Transformation of primary myelofibrosis with 20q- in Philadelphia-positive acute lymphoblastic leukemia: case report and review of literature.

University of Kragujevac, Faculty of Medicine, Kragujevac, Serbia.
Pathology - Research and Practice (impact factor: 1.21). 05/2012; 208(7):420-3. DOI:10.1016/j.prp.2012.04.007
Source: PubMed

ABSTRACT A 56-year-old male with chronic idiopathic myelofibrosis and cytogenetic finding of 20q- after a period of 10 months developed acute Philadelphia-positive lymphoblastic leukemia. Immunophenotyping of peripheral blood by flow cytometry showed HLA-DR, CD34, CD19, CD22, CD10, CD33, and CD11b positivity. Cytogenetic analysis revealed the presence of 20q- and Philadelphia chromosome t(9;22)(q34:q11) at the time of disease transformation to ALL. The JAK2V617F mutation was not found. This is a very rare case of simultaneous presence of two cytogenetics abnormalities and evolution of primary idiopathic myelofibrosis to Philadelphia-positive acute lymphoblastic leukemia.

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Keywords

10 months
 
56-year-old male
 
acute Philadelphia-positive lymphoblastic leukemia
 
CD11b positivity
 
chronic idiopathic myelofibrosis
 
cytogenetic
 
Cytogenetic analysis
 
cytogenetics abnormalities
 
disease transformation
 
flow cytometry
 
Philadelphia-positive acute lymphoblastic leukemia
 
primary idiopathic myelofibrosis
 
rare case