Hallucinations and comorbid renal tubular acidosis caused by topiramate in a patient with psychiatric history

Department of psychiatry, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510630, Guangdong Province, People's Republic of China
General hospital psychiatry (Impact Factor: 2.9). 05/2012; 35(2). DOI: 10.1016/j.genhosppsych.2012.04.008
Source: PubMed

ABSTRACT Few studies have shown that topiramate may induce psychiatric symptoms and metabolic disorders, respectively. Here, we reported a 13-year-old female who presented with topiramate-induced hallucinations and comorbid renal tubular acidosis. She had a history of psychiatric illness and had been taking the medication for 3 months without prior side effects. After the discontinuation of topiramate, she was treated with supplementary potassium and sodium bicarbonate. Subsequently, her psychiatric symptoms and biochemical findings improved. Recognition of drug-induced psychotic symptoms and renal tubular acidosis is important during concomitant topiramate therapy in psychiatric clinic.

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