Article

Polarity and lymphocyte fate determination.

Department of Medicine, University of California San Diego, La Jolla, CA, USA.
Current opinion in cell biology (impact factor: 14.15). 06/2012; 24(4):526-33. DOI:10.1016/j.ceb.2012.05.002 pp.526-33
Source: PubMed

ABSTRACT Polarity within lymphocytes has been recognized to regulate a variety of processes, including migration, signaling, and the execution of effector function. It has been recently proposed, however, that this polarized behavior may also serve a different purpose in lymphocytes that have not yet encountered their foreign antigen-to coordinate asymmetric cell division. Asymmetric division is an evolutionarily conserved mechanism allowing a single cell to give rise to two distinct daughter cells from inception. In this review, recent findings in polarity and asymmetric division in lymphocytes are discussed.

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Keywords

asymmetric cell division
 
Asymmetric division
 
evolutionarily conserved mechanism
 
foreign antigen-to
 
inception
 
lymphocytes
 
polarity
 
processes
 
single cell
 

John T Chang