Article

Comparative evaluation of Zidovudine loaded hydrogels and emulgels

International Journal of Pharmacy and Technology 01/2012; 5(1):41-45.

ABSTRACT Zidovudine (AZT) is the widely used anti-retroviral drug associated with serious gastric side effects upon oral delivery also having short half life and poor partition coefficient. Upon oral administration it also undergoes first pass metabolism. Transdermal delivery of AZT encounters all the problems associated with oral route. The present study we developed hydrogels as well as emugels loaded with AZT and investigated the ability of hydrogels as well as emulgels to deliver the AZT via transdermal route. All the gels were evaluated for their physical properties, drug content, viscosity, pH, spreadability and in vitro drug release. In vitro release pattern for all the formulations were
found to be zero order diffusion controlled release. All the formulations were found to be compatible with skin and stable as per ICH guidelines. Among all the formulations emulgels were found to be effective vehicles for delivery AZT because of the effective partition in both oil and aqueous phases.

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    ABSTRACT: Emulgel is an emerging topical drug delivery system to which if more effort is paid towards its formulation & development with more number of topically effective drugs it will prove a boon for derma care & cosmetology. Emulgels are either emulsion of oil in water or water in oil type, which is gelled by mixing it with gelling agent. Incorporation of emulsion into gel increases its stability & makes it a dual control release system. Due to lack of excess oily bases & insoluble excipients, it shows better drug release as compared to other topical drug delivery system. Presence of gel phase makes it a non greasy & favors good patient compliance. These reviews gives knowledge about Emulgel including its properties, advantages, formulation considerations, and its recent advances in research field. All factors such as selection of gelling agent, oil agent, emulsifiers influencing the stability and efficacy of Emulgel are discussed. All justifications are described in accordance with the research work carried out by various scientists. These brief reviews on formulation method has been included. Current researched that work carried out on Emulgel are also discussed and highlighted the wide utility of Emulgel in topical drug delivery system. After the vast study, it can be concluded that the Emulgels appear better & effective drug delivery system as compared to other topical drug delivery system. The comprehensive analysis of rheological and release properties will provide an insight into the potential usage of Emulgel formulation as drug delivery system.
    Journal of Controlled Release 07/2013; · 7.63 Impact Factor

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