Article

The effects of dietary flavonoids on the regulation of redox inflammatory networks.

Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Rome, Italy.
Frontiers in Bioscience (Impact Factor: 3.29). 01/2012; 17:2396-418.
Source: PubMed

ABSTRACT Dietary flavonoids are a large family of polyphenols ubiquitously expressed in plants. Recent evidence show that flavonoids possess several anti-inflammatory activities due to their ability to scavenge reactive oxygen and nitrogen species (ROS and RNS), to inhibit the pro-inflammatory activity of ROS-generating enzymes including cyclooxygenase (COX), lipoxygenase (LOX) and inducible nitric oxide synthase (iNOS) and to modulate different intracellular signaling pathways from NF-kB to mitogen-activated protein kinases (MAPKs) through perturbation of redox-sensible networks in immune cells. This report will review current knowledge on the anti-inflammatory effects of flavonoids on immune cells focusing on their ability to modulate multiple redox-sensible pathways involved in inflammation.

2 Bookmarks
 · 
165 Views
  • [Show abstract] [Hide abstract]
    ABSTRACT: Polyphenols from red fruits and bee-derived propolis (PR) are bioactive natural products in various in vitro and in vivo models. The present study shows that hematotoxicity-free doses of grape polyphenols (GPE) and PR differentially decreased the secretion of pro-inflammatory cytokines from activated human peripheral blood leucocytes. While GPE inhibited the monocytes/macrophage response, propolis decreased both monokines and interferon γ (IFNγ) production. When used together, their distinct effects lead to the attenuation of all inflammatory mediators, as supported by a significant modulation of the transcriptomic profile of pro-inflammatory genes in human leukocytes. To enforce in vitro data, GPE+PR were tested for their ability to improve clinical scores and cachexia in chronic rat adjuvant-induced arthritis (AA). Extracts significantly reduced arthritis scores and cachexia, and this effect was more significant in animals receiving continuous low doses compared to those receiving five different high doses. Animals treated daily had significantly better clinical scores than corticoid-treated rats. Together, these findings indicate that the GPE+PR combination induces potent anti-inflammatory activity due to their complementary immune cell modulation.
    Phytomedicine: international journal of phytotherapy and phytopharmacology 09/2013; · 2.97 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Background: Flavonoids are natural phenolic compounds with antioxidant, anti-inflammatory and antimicrobial capacity. This study aimed to investigate the effects of different flavonoids for potential use in periodontal applications. Materials and Methods: Cultures of Staphylococcus epidermidis or primary human gingival fibroblasts (HGF) were treated with different doses of chrysin, diosmetin, galangin, quercitrin and taxifolin. The effect of these molecules was evaluated on S. epidermidis growth rate and on HGF viability, gene expression, collagen production, reactive oxygen species (ROS) levels, wound healing and matrix metalloproteinase-1 (MMP1) and metallopeptidase inhibitor-1 (TIMP1) production. Results: Among all the screened flavonoids, quercitrin showed the most promising biological effects, both in HGF and in S. epidermidis. Thus, quercitrin was not toxic for HGF, increased collagen IIIα1, decorin and dowregulated interleukin-6 mRNA levels, decreased the expression of pro-fibrotic markers during wound healing, decreased ROS levels in basal and stimulated conditions and decreased the MMP1/TIMP1 ratio. Quercitrin also decreased bacterial growth rate. Conclusion: Results suggest that quercitrin could contribute to protect and recover the integrity of gingival tissues, thus, displaying a potential use for periodontal disease treatment or to functionalize dental implant abutments to improve soft tissue integration. Further studies are required to confirm the role of quercitrin in gingival tissues.
    Journal of Periodontology 02/2014; · 2.40 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: The properties of essential oils obtained from Ferula assa-foetida oleo-gum-resins (OGRs) collectioned in three collections times in 15 June (OGR1), 30 June (OGR2) and 15 July (OGR3) 2011 was investigated. Essential oil from OGR1 was constituted high levels of (E)-1-propenyl sec-butyl disulfide (23.9%) and 10-epi-γ-eudesmol (15.1%). Essential oil from OGR2 was constituted high levels of (Z)-1-propenyl sec-butyl disulfide (27.7%) and (E)-1-propenyl sec-butyl disulfide (20.3%). Essential oil from OGR3 was constituted high levels of β-pinene (47.1%) and α-pinene (21.3%). Inhibitory concentration (IC50) for radical scavenging were 0.012-0.035, 0.025-0.047 and 0.035-0.066mg/ml of essential oil obtained from OGR1, OGR2 and OGR3, respectively. Minimal inhibitory concentration (MIC) for Gram-positive and Gram-negative bacteria and fungi grpwth were 0.028-0.111, 0.027-0.107 and 0.018-0.058mg/ml of essential oil obtained from OGR1, OGR2 and OGR3, respectively. Essential oils obtained from different OGRs have different composition and biological activity thus have different applications in food and health industry.
    Food Chemistry 06/2013; 138(4):2180-7. · 3.33 Impact Factor

Full-text

View
142 Downloads
Available from
May 28, 2014