Article

The effects of dietary flavonoids on the regulation of redox inflammatory networks.

Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Rome, Italy.
Frontiers in Bioscience (impact factor: 3.52). 01/2012; 17:2396-418. pp.2396-418
Source: PubMed

ABSTRACT Dietary flavonoids are a large family of polyphenols ubiquitously expressed in plants. Recent evidence show that flavonoids possess several anti-inflammatory activities due to their ability to scavenge reactive oxygen and nitrogen species (ROS and RNS), to inhibit the pro-inflammatory activity of ROS-generating enzymes including cyclooxygenase (COX), lipoxygenase (LOX) and inducible nitric oxide synthase (iNOS) and to modulate different intracellular signaling pathways from NF-kB to mitogen-activated protein kinases (MAPKs) through perturbation of redox-sensible networks in immune cells. This report will review current knowledge on the anti-inflammatory effects of flavonoids on immune cells focusing on their ability to modulate multiple redox-sensible pathways involved in inflammation.

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Keywords

anti-inflammatory activities
 
anti-inflammatory effects
 
COX
 
Dietary flavonoids
 
immune cells
 
inducible nitric oxide synthase
 
inflammation
 
large family
 
mitogen-activated protein kinases
 
modulate different intracellular signaling pathways
 
nitrogen species
 
perturbation
 
plants
 
pro-inflammatory activity
 
Recent evidence
 
ROS-generating enzymes
 
scavenge reactive oxygen