Article

Poly(ethylene carbonate) nanoparticles as carrier system for chemotherapy showing prolonged in vivo circulation and anti-tumor efficacy.

Department of Pharmaceutics and Biopharmacy, Philipps-Universität Marburg, Marburg, Germany.
Macromolecular Bioscience (impact factor: 3.89). 05/2012; 12(7):970-8. DOI:10.1002/mabi.201100499 pp.970-8
Source: PubMed

ABSTRACT The aim of this study is to investigate the feasibility and efficacy of PEC nanoparticles as delivery system for cancer chemotherapy. Assembly of paclitaxel-loaded nanoparticles with high loading efficiency and narrow-size distribution is successful. For non-invasive in vivo tracing, nanoparticle blends of chelator bearing poly(lactide) with PEC and PLGA are successfully prepared. Pharmacokinetic studies in mice reveal a twofold higher circulation time of PEC as compared to PLGA. A tumor model shows an accumulation of PEC NPs in cancerous tissue and a higher anti-tumor efficiency compared to the standard Taxol™, which is reflected in a significantly slower tumor growth compared to the NaCl control group.

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Keywords

accumulation
 
cancer chemotherapy
 
cancerous tissue
 
chelator bearing poly(lactide)
 
delivery system
 
mice
 
nanoparticle blends
 
narrow-size distribution
 
non-invasive
 
paclitaxel-loaded nanoparticles
 
PEC nanoparticles
 
Pharmacokinetic studies
 
slower tumor growth
 
standard Taxol™
 
twofold higher circulation time