Proliferative and Nonproliferative Lesions of the Rat and Mouse Central and Peripheral Nervous Systems

Merck KGaA, Darmstadt, Germany.
Toxicologic Pathology (Impact Factor: 2.14). 05/2012; 40(4 Suppl):87S-157S. DOI: 10.1177/0192623312439125
Source: PubMed


Harmonization of diagnostic nomenclature used in the pathology analysis of tissues from rodent toxicity studies will enhance the comparability and consistency of data sets from different laboratories worldwide. The INHAND Project (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) is a joint initiative of four major societies of toxicologic pathology to develop a globally recognized nomenclature for proliferative and nonproliferative lesions in rodents. This article recommends standardized terms for classifying changes observed in tissues of the mouse and rat central (CNS) and peripheral (PNS) nervous systems. Sources of material include academic, government, and industrial histopathology databases from around the world. Covered lesions include frequent, spontaneous, and aging-related changes as well as principal toxicant-induced findings. Common artifacts that might be confused with genuine lesions are also illustrated. The neural nomenclature presented in this document is also available electronically on the Internet at the goRENI website (

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    • "Recently, the STP has undertaken a major harmonization exercise for rodent pathology – the INHAND (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) initiative [16]. So far this group has reported on the hepaticobiliary, respiratory, nervous and urinary systems [17-20]. For some time the National Cancer Institute’s Mouse Models of Human Cancer consortium (MMHCC) has been examining the classification of tumours in genetically engineered mice. "
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    Journal of Biomedical Semantics 09/2013; 4(1):18. DOI:10.1186/2041-1480-4-18 · 2.26 Impact Factor
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    • "All sections of CNS tissues with tumors were reviewed according to the International Harmonization of Nomenclature and Diagnostic Criteria (INHAND)8. "
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    ABSTRACT: In order to accurately assess the carcinogenicity of chemicals with regard to rare tumors such as rat CNS tumors, sufficient information about spontaneous tumors are very important. This paper presents the data on the type, incidence and detected age of CNS tumors in F344/DuCrlCrlj (a total of 1363 males and 1363 females) and Crl:CD(SD) rats (a total of 1650 males and 1705 females) collected from in-house background data-collection studies and control groups of carcinogenicity studies at our laboratory, together with those previously reported in F344 and SD rats. The present data on F344/DuCrlCrlj rats (F344 rats) and Crl:CD(SD) rats (SD rats) clarified the following. (1) The incidences of all CNS tumors observed in F344 rats were less than 1%. (2) The incidences of malignant astrocytoma and granular cell tumor were higher in male SD rats than in female SD rats. (3) The incidences of astrocytoma and granular cell tumor were higher in SD rats than in F344 rats. (4) Among astrocytoma, oligodendroglioma and granular cell tumor, oligodendroglioma was detected at the youngest age, followed by astrocytoma, and ultimately, granular cell tumor developed in both strains. The incidences observed in our study were almost consistent with those previously reported in F344 and SD rats.
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