Article

Glioblastoma multiforme imaging: the role of nuclear medicine.

Department of Neurosurgery, University Hospital of Ioannina, P.O. BOX 103, Neohoropoulo, 45500 Ioannina, Greece. .
Current radiopharmaceuticals 05/2012; 5(4):308-13.
Source: PubMed

ABSTRACT Glioblastoma multiforme (GBM) is the most common and most malignant primary brain tumor occurring during adulthood. The incidence of GBM is nearly 5 cases per 100,000 population per year. The standard of care for newly diagnosed GBM includes surgical resection when possible, followed by radiotherapy and concomitant and adjuvant chemotherapy with temozolomide. Imaging modalities used in nuclear medicine, namely positron emission tomography (PET) and single-photon emission computed tomography (SPECT) have been employed towards the evaluation of brain tumors. Herewith, we discuss the value of the above imaging techniques in the assessment of GBM aggressiveness, in the distinction of treatment induced necrosis from glioma recurrence, in the estimation of overall prognosis and in the evaluation of treatment response in patients with GBM.

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Keywords

adjuvant chemotherapy
 
brain tumors
 
common
 
estimation
 
GBM aggressiveness
 
Glioblastoma multiforme
 
glioma recurrence
 
imaging techniques
 
malignant primary brain tumor
 
positron emission tomography
 
prognosis
 
single-photon emission computed tomography
 
surgical resection
 
treatment induced necrosis