Article

The development of FtsZ inhibitors as potential antibacterial agents.

Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, Jinan 250012, PR China.
ChemMedChem (impact factor: 3.15). 05/2012; 7(7):1161-72. DOI:10.1002/cmdc.201200156 pp.1161-72
Source: PubMed

ABSTRACT The emergence and prevalence of bacterial resistance has resulted in a clear demand for novel antibacterial drugs. As a tubulin homologue, FtsZ is an essential cell-division protein in prokaryotic organisms and is showing increasing promise as a target for antibacterial drug discovery. This review describes the role of FtsZ in bacterial cytokinesis and various FtsZ inhibitors, with particular focus on their discovery, antibacterial activities, mechanisms of action, synthetic methods, and representative analogues.

0 0
 · 
1 Bookmark
 · 
87 Views
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.

Keywords

antibacterial activities
 
antibacterial drug discovery
 
bacterial cytokinesis
 
bacterial resistance
 
clear demand
 
essential cell-division protein
 
FtsZ
 
novel antibacterial drugs
 
prokaryotic organisms
 
representative analogues
 
tubulin homologue
 
various FtsZ inhibitors
 

Siti Ma