Article

Sleep disturbance, inflammation and depression risk in cancer survivors

University of California, Los Angeles - Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, CA, United States.
Brain Behavior and Immunity (Impact Factor: 6.13). 05/2012; 30. DOI: 10.1016/j.bbi.2012.05.002
Source: PubMed

ABSTRACT Over two-thirds of the 11.4 million cancer survivors in the United States can expect long-term survival, with many others living with cancer as a chronic disease controlled by ongoing therapy. However, behavioral co-morbidities often arise during treatment and persist long-term to complicate survival and reduce quality of life. In this review, the inter-relationships between cancer, depression, and sleep disturbance are described, with a focus on the role of sleep disturbance as a risk factor for depression. Increasing evidence also links alterations in inflammatory biology dynamics to these long-term effects of cancer diagnosis and treatment, and the hypothesis that sleep disturbance drives inflammation, which together contribute to depression, is discussed. Better understanding of the associations between inflammation and behavioral co-morbidities has the potential to refine prediction of risk and development of strategies for the prevention and treatment of sleep disturbance and depression in cancer survivors.

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Available from: Michael R Irwin, Aug 25, 2015
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    • "It is important to note that some cancer-related sequelae tend to co-occur, prompting research on symptom clusters such as depression, fatigue, and pain (Jaremka et al., 2013; Reyes-Gibby, Aday, Anderson, Mendoza, & Cleeland, 2006). Although some evidence suggests that the experience of sleep disturbance and fatigue may precede the onset of depressive symptoms and pain in the reentry and early survivorship periods (Irwin, Olmstead, Ganz, & Haque, 2013; Trudel-Fitzgerald, Savard, & Ivers, 2013), other research has not established temporal precedence (Krebber et al., 2014). "
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