Sleep disturbance, inflammation and depression risk in cancer survivors

University of California, Los Angeles - Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, CA, United States.
Brain Behavior and Immunity (Impact Factor: 5.89). 05/2012; 30. DOI: 10.1016/j.bbi.2012.05.002
Source: PubMed


Over two-thirds of the 11.4 million cancer survivors in the United States can expect long-term survival, with many others living with cancer as a chronic disease controlled by ongoing therapy. However, behavioral co-morbidities often arise during treatment and persist long-term to complicate survival and reduce quality of life. In this review, the inter-relationships between cancer, depression, and sleep disturbance are described, with a focus on the role of sleep disturbance as a risk factor for depression. Increasing evidence also links alterations in inflammatory biology dynamics to these long-term effects of cancer diagnosis and treatment, and the hypothesis that sleep disturbance drives inflammation, which together contribute to depression, is discussed. Better understanding of the associations between inflammation and behavioral co-morbidities has the potential to refine prediction of risk and development of strategies for the prevention and treatment of sleep disturbance and depression in cancer survivors.

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Available from: Michael R Irwin, Oct 10, 2015
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    • "It is important to note that some cancer-related sequelae tend to co-occur, prompting research on symptom clusters such as depression, fatigue, and pain (Jaremka et al., 2013; Reyes-Gibby, Aday, Anderson, Mendoza, & Cleeland, 2006). Although some evidence suggests that the experience of sleep disturbance and fatigue may precede the onset of depressive symptoms and pain in the reentry and early survivorship periods (Irwin, Olmstead, Ganz, & Haque, 2013; Trudel-Fitzgerald, Savard, & Ivers, 2013), other research has not established temporal precedence (Krebber et al., 2014). "
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    ABSTRACT: The number of individuals living with a history of cancer is estimated at 13.7 million in the United States and is expected to rise with the aging of the population. With expanding attention to the psychosocial and physical consequences of surviving illness, psychological science and evidence-based practice are making important contributions to addressing the pressing needs of cancer survivors. Research is demonstrating that adults diagnosed with cancer evidence generally positive psychosocial adjustment over time; however, a subset is at risk for compromised psychological and physical health stemming from long-term or late effects of cancer and its treatment. In this article, we characterize survivorship after medical treatment completion during the periods of reentry, early survivorship, and long-term survivorship. We describe the major psychosocial and physical sequelae facing adults during those periods, highlight promising posttreatment psychosocial and behavioral interventions, and offer recommendations for future research and evidence-based practice. (PsycINFO Database Record (c) 2015 APA, all rights reserved).
    American Psychologist 02/2015; 70(2):159-174. DOI:10.1037/a0037875 · 6.87 Impact Factor
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    • "The empirical paper by Witek-Jansek et al. in this volume explores whether childhood adversity is associated with vulnerability for intense sustained behavioral symptoms, including fatigue and depressive symptoms, and quality of life and immune dysregulation (Witek Janusek et al., 2012). Irwin and colleagues describe the common presentation of sleep disturbance and depression in cancer survivors (Irwin et al., 2012). The authors outline a model in which sleep disturbance drives alterations in inflammatory biology, which result in of depressive symptoms and in clinical depression for some. "
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    Brain Behavior and Immunity 01/2013; 30. DOI:10.1016/j.bbi.2013.01.003 · 5.89 Impact Factor
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    ABSTRACT: Studies have consistently shown cancer diagnosis and treatment to be associated with increased depression. However, research that directly examines the depression and coping strategies of older minority cancer survivors is sparse. Addressing that gap, this study examines depression and coping strategies among older Korean immigrant cancer survivors. A qualitative method approach was utilized by interviewing 15 survivors from the state of New York (NY) and nine from Minnesota (MN). Each interview was digitally audio-recorded and transcribed verbatim in Korean. Grounded theory was employed to analyze the data, using Atlas ti 5.0. Analysis of the MN interviews showed two depression factors: (1) physical deterioration and (2) fear of death. For the NY interviews, analysis highlighted the following factor: loneliness due to disconnectedness from community. Analysis of the MN and the NY interviews for depression coping strategies revealed two primary internal coping strategies: (1) reliance on religion through prayer and (2) psychological strength by avoiding negative thoughts. For external strategies, analysis suggested three shared strategies: (1) social and religious support, (2) medical service utilization, and (3) health management by exercise. Regional differences related to depression factors imply that survivors living in the NY area may need more social support, whereas survivors living in the MN area may need more knowledge around physical changes that follow cancer treatment. Regional similarities across results indicate that availability of social support is a critical factor relieving depression. Thus, specialized intervention programs for reducing depression among cancer survivors should consider regional features.
    Journal of Psychosocial Oncology 07/2013; 31(4):357-376. DOI:10.1080/07347332.2013.798756 · 1.04 Impact Factor
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