Article

Ajugalide-B (ATMA) is an anoikis-inducing agent from Ajuga taiwanensis with antiproliferative activity against tumor cells in vitro.

Division of Herbal Medicine and Natural Product, National Research Institute of Chinese Medicine, Taipei 112, Taiwan, Republic of China.
Phytochemistry (impact factor: 3.35). 05/2012; 80:64-9. DOI:10.1016/j.phytochem.2012.05.005 pp.64-9
Source: PubMed

ABSTRACT Ajuga taiwanensis is widely used for the treatment of hepatitis and hepatoma in Taiwanese folk medicine. However, its bioactive components and mechanism of action are unclear. Herein, ajugalide-B (ATMA), a neoclerodane diterpenoid isolated from Ajuga taiwanensis, is reported to exhibit high anti-proliferative activity against tumor cell lines from various tissues. These results demonstrate that ATMA disrupts the focal adhesion complex by decreasing phosphorylation of paxillin and focal adhesion kinase (FAK). As a result, anoikis, a specific type of apoptosis caused by detachment of cells, is triggered by activation of caspase-8 in A549 cells. Furthermore, ATMA also blocks anchorage-independent growth and cell migration and, therefore, ATMA may serve as a lead compound for the developing of anti-cancer therapeuties with anoikis-inducing properties.

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Keywords

anti-cancer therapeuties
 
ATMA
 
ATMA disrupts
 
bioactive components
 
caspase-8
 
decreasing phosphorylation
 
focal adhesion complex
 
focal adhesion kinase
 
Herein
 
neoclerodane diterpenoid
 
specific type
 
Taiwanese folk medicine
 
tumor cell lines
 

Chun-Tang Chiou