Article

Adiponectin and its receptors modulate granulosa cell and cumulus cell functions, fertility, and early embryo development in the mouse and human.

Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA.
Fertility and sterility (impact factor: 3.97). 05/2012; 98(2):471-9.e1. DOI:10.1016/j.fertnstert.2012.04.050 pp.471-9.e1
Source: PubMed

ABSTRACT To study the expression and function of adiponectin and its receptors in mouse and human follicle cells and in early embryo development.
Whole ovaries, granulosa cells, and cumulus-oocyte complexes isolated from immature mice before and during hormone-induced ovulation were used to analyze the expression of adiponectin, its receptors, and ovulation-related genes; human cumulus cells and granulosa cells were isolated from patients undergoing in vitro fertilization (IVF) procedures.
Multicenter.
Women in IVF programs in Japan and the United States.
None.
Expression of adiponectin receptors and fertility.
Adiponectin expression is absent/low in mouse and human granulosa cells and cumulus cells. Adiponectin receptors are hormonally regulated in mouse granulosa and cumulus cells in vivo and in culture. Adiponectin differentially alters the expression of Adipor1/Adipor2 as well as genes related to steroidogenesis, ovulation, and apoptosis in cumulus cells versus granulosa cells. Adiponectin enhances oocyte maturation and early embryo development in mouse and human IVF procedures.
Adiponectin can modulate not only follicle growth but also embryo development in mice and humans.

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Keywords

Adiponectin
 
Adiponectin enhances oocyte maturation
 
Adiponectin expression
 
adiponectin receptors
 
Adipor1/Adipor2
 
cumulus cells
 
cumulus-oocyte complexes
 
granulosa cells
 
hormone-induced ovulation
 
human cumulus cells
 
human follicle cells
 
human granulosa cells
 
human IVF procedures
 
IVF programs
 
mouse granulosa
 
ovulation-related genes
 
patients undergoing
 
United States
 
vitro fertilization
 
Whole ovaries