Article

Serum level of interleukin-6 in Chinese patients with multiple sclerosis.

Department of Neurology, Ruijin Hospital, Medical School of Shanghai Jiao Tong University, Shanghai, China; School of Public Health, Shanghai Jiao Tong University, Shanghai, China.
Journal of neuroimmunology (impact factor: 2.84). 05/2012; 249(1-2):109-11. DOI:10.1016/j.jneuroim.2012.04.015
Source: PubMed

ABSTRACT The aim of this study was to investigate the serum concentration of interleukin (IL)-6 in patients with relapsing-remitting MS (RR-MS), compare the difference between males and females, and explore the correlation between the serum concentration of IL-6 and clinical parameters like the current age, the age at onset, disease duration, disability (expanded disability status scale, EDSS), and the number of relapse. We compared the serum concentration of IL-6 in 39 patients with MS and 39 healthy controls matched with sex and age. The serum IL-6 concentration was measured by FlowCytomix. Compared to healthy controls, both the frequency of subjects with detectable level of IL-6 (P=0.005) and the serum concentration of IL-6 (P=0.004) were significantly higher in MS patients. When data were analyzed by gender, statistical significances between MS patients and healthy controls were observed only in females, although the frequency with detectable level and the serum concentration of IL-6 were higher in male MS patients than male controls. The serum level of IL-6 was found to be significantly positively correlated with the number of relapse for female MS patients (r(s)=0.511, P=0.009), with the current age for male MS patients (r(s)=0.700, P=0.005), and with the age at onset for all MS patients (r(s)=0.351, P=0.028). Our results may support that IL-6 is involved in the pathogenesis of MS and indicate that differences exist between male and female patients.

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    Article: Cytokine profile in relapsing‑remitting multiple sclerosis patients and the association between progression and activity of the disease.
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    Molecular Medicine Reports 01/2013; · 0.42 Impact Factor
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Keywords

39 healthy controls
 
39 patients
 
clinical parameters
 
current age
 
detectable level
 
differences
 
disability status scale
 
disease duration
 
female MS patients
 
female patients
 
females
 
healthy controls
 
IL-6
 
male MS patients
 
MS patients
 
relapsing-remitting MS
 
serum concentration
 
serum IL-6 concentration
 
serum level
 
statistical significances
 

Ying-Chun Chen