Article

Invertebrate FMRFamide Related Peptides.

Department of Biological Sciences, Southern Illinois University Edwardsville, Illinois Box 1651, Edwardsville, IL 62026-1651. .
Protein and Peptide Letters (Impact Factor: 1.74). 05/2012; DOI: 10.2174/0929866511320060005
Source: PubMed

ABSTRACT In 1977 the neuropeptide FMRFamide was isolated from the clam, Macrocallista nimbosa. Since then several hundred FMRFamide-related peptides (FaRPs) have been isolated from invertebrate animals. Precursors to the FaRPs likely arose in the cnidarians. With the transition to a bilateral body plan FaRPs became a fixture in the invertebrate phyla. They have come to play a critical role as neurotransmitters, neuromodulators, and neurohormones. FaRPs regulate a variety of body functions including, feeding, digestion, circulation, reproduction, movement. The evolution of the molecular form and function of these omnipresent peptides will be considered.

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