Article

Comparison of the kidney fungal burden in experimental disseminated candidiasis by species of the Candida parapsilosis complex treated with fluconazole, amphotericin B and caspofungin in a temporarily neutropenic murine model.

Department of Medical Microbiology, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary.
Chemotherapy (impact factor: 1.82). 05/2012; 58(2):159-64. DOI:10.1159/000337088 pp.159-64
Source: PubMed

ABSTRACT The efficacy of fluconazole (FLU), amphotericin B (AMB) and caspofungin (CAS) was tested against three Candida orthopsilosis, three C. metapsilosis and two C. parapsilosis sensu stricto isolates in neutropenic mice.
Mice were immunosuppressed by 200 mg/kg cyclophosphamide. Five-day intraperitoneal treatment was started 24 h after infection. Kidney burden was analyzed using the Kruskal-Wallis test.
FLU 10 and 20 mg/kg as well as AMB 1 mg/kg significantly decreased the fungal burden (p < 0.05) for all eight isolates of the three species. CAS 2 and 5 mg/kg were efficacious against all C. orthopsilosis and C. metapsilosis isolates (p < 0.05), but only 5 mg/kg CAS was effective against C. parapsilosis isolates (p < 0.05).
The efficacy of FLU and AMB against the three species was comparable. Though the activity of CAS was higher against C. orthopsilosis and C. metapsilosis, the current treatment guidelines for C. parapsilosis sensu stricto seem to be applicable to other 'psilosis' species.

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Keywords

200 mg/kg cyclophosphamide
 
AMB 1 mg/kg
 
applicable
 
C. metapsilosis
 
C. orthopsilosis
 
C. parapsilosis
 
C. parapsilosis sensu stricto
 
Candida orthopsilosis
 
CAS 2
 
caspofungin
 
current treatment guidelines
 
Five-day intraperitoneal treatment
 
FLU
 
fluconazole
 
fungal burden
 
Kidney burden
 
Kruskal-Wallis test
 
Mice
 
neutropenic mice
 
three species