Which Obesity Index Best Correlates With Prostate Volume, Prostate-specific Antigen, and Lower Urinary Tract Symptoms?

Department of Urology, Soonchunhyang University, Seoul Hospital, Seoul, Korea.
Urology (Impact Factor: 2.13). 05/2012; 80(1):187-90. DOI: 10.1016/j.urology.2012.04.003
Source: PubMed

ABSTRACT To determine which measurement variable, waist circumference (WC), body mass index (BMI), or waist-to-hip ratio (WHR) is most closely related to the prostate volume (PV), prostate-specific antigen (PSA), and lower urinary tract symptoms (LUTS).
Between January 2010 and September 2011, 1632 consecutive ostensibly healthy Korean men aged 40-69 years who visited our clinic for a prostate checkup were enrolled into the study. Exclusion criteria included pyuria, history of lower urinary tract disorder influencing urination, and a high PSA level of >3.0 ng/mL. All men underwent a detailed clinical evaluation using the International Prostate Symptom Score (I-PSS) questionnaire. Anthropometric measurements were determined. Serum PSA, urinalysis, and transrectal ultrasound were also performed.
Data from 1601 men were analyzed. The mean age was 51.6 years, WC 83.7 cm, BMI 24.8 kg/m(2), PV 24.6 mL, and the mean PSA level was 1.07 ng/mL. Using multivariate analysis, PV most positively associated with WC (P < .001), while PSA level had negatively associated with BMI (P = .036) and no significant association with WC or WHR was noted. There was no significant relationship between various obesity indexes and I-PSS.
Our data showed that PV positively associated with central obesity, as represented by WC. In contrast, serum PSA negatively associated with BMI, which represented overall obesity (ie, hemodilution). Our data also suggested that obesity is not associated with lower urinary tract symptoms in Korean men.

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    ABSTRACT: Objective To investigate the impact of metabolic syndrome (MS) on lower urinary tract symptoms (LUTS) in middle-aged men. Materials and Methods A total of 4256 ostensibly healthy native Korean men aged between 40 and 65 years who voluntarily underwent medical checkup were enrolled. Participants' demographics were collected including International Prostate Symptom Score, various metabolic risk factors, and prostate volume (PV). All participants were stratified into 2 groups based on the presence or absence of MS. The PV was used for subgroup analysis. Results Data from 4076 men were retrospectively analyzed. The mean age was 52.2 ± 7.4 years and 18.5% of patients were included in the MS group. The MS group had lower frequency score (P <.01) compared with the non-MS group. In the larger PV group (≥28 mL), the age-adjusted odds ratio (OR) for having moderate-to-severe LUTS was significantly lower in subjects with MS having 3 metabolic risk factors (hypertension and hypertriglyceridemia included; OR, 0.666; P <.01) and in subjects with MS having 4 or 5 risk factors (OR, 0.612; P <.05) compared with the non-MS group. Conclusion We confirmed that MS with increasing number of MS risk factors (especially hypertension and hypertriglyceridemia) had favorable effects on the likelihood of having moderate-to-severe LUTS in middle-aged men with larger PV.
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    ABSTRACT: To determine the use of the prostate specific antigen (PSA) level and digital rectal examination (DRE) findings to estimate the resected tissue weight (RTW) before transurethral resection of the prostate (TURP).
    11/2014; 12(4). DOI:10.1016/j.aju.2014.09.006
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