Which obesity index best correlates with prostate volume, prostate-specific antigen, and lower urinary tract symptoms?

Department of Urology, Soonchunhyang University, Seoul Hospital, Seoul, Korea.
Urology (Impact Factor: 2.42). 05/2012; 80(1):187-90. DOI: 10.1016/j.urology.2012.04.003
Source: PubMed

ABSTRACT To determine which measurement variable, waist circumference (WC), body mass index (BMI), or waist-to-hip ratio (WHR) is most closely related to the prostate volume (PV), prostate-specific antigen (PSA), and lower urinary tract symptoms (LUTS).
Between January 2010 and September 2011, 1632 consecutive ostensibly healthy Korean men aged 40-69 years who visited our clinic for a prostate checkup were enrolled into the study. Exclusion criteria included pyuria, history of lower urinary tract disorder influencing urination, and a high PSA level of >3.0 ng/mL. All men underwent a detailed clinical evaluation using the International Prostate Symptom Score (I-PSS) questionnaire. Anthropometric measurements were determined. Serum PSA, urinalysis, and transrectal ultrasound were also performed.
Data from 1601 men were analyzed. The mean age was 51.6 years, WC 83.7 cm, BMI 24.8 kg/m(2), PV 24.6 mL, and the mean PSA level was 1.07 ng/mL. Using multivariate analysis, PV most positively associated with WC (P < .001), while PSA level had negatively associated with BMI (P = .036) and no significant association with WC or WHR was noted. There was no significant relationship between various obesity indexes and I-PSS.
Our data showed that PV positively associated with central obesity, as represented by WC. In contrast, serum PSA negatively associated with BMI, which represented overall obesity (ie, hemodilution). Our data also suggested that obesity is not associated with lower urinary tract symptoms in Korean men.

  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: To determine the use of the prostate specific antigen (PSA) level and digital rectal examination (DRE) findings to estimate the resected tissue weight (RTW) before transurethral resection of the prostate (TURP).
    Arab Journal of Urology. 11/2014;
  • [Show abstract] [Hide abstract]
    ABSTRACT: To determine the relationship between obesity and febrile urinary tract infection (UTI) in young children. We reviewed all medical records of children aged <3 years who visited our institution for febrile UTIs and infant national health checkups (controls) between January 2008 and February 2012. All subjects were subcategorized into 3 groups of lean, overweight, and obese using weight-for-length measurements. The effect of obesity on UTI risk was evaluated and odds ratios were calculated. We analyzed 465 patients with UTIs and 812 controls. The proportion of overweight and obese children was higher in patients with UTIs (22.8%) and acute pyelonephritis (APN; 31.1%) compared with those in the control (11.7%; P <.05). After adjusting for age and gender, the odds ratio (OR) of UTI in obese relative to lean children was 1.84 (95% confidence interval [CI], 1.11-3.05) and that of APN was 2.43 (95% CI, 1.27-4.62). The OR of APN in overweight relative to lean children was 1.96 (95% CI, 1.11-3.46). After adjusting for age, the OR of APN in obese relative to lean boys was 2.74 (95% CI, 1.11-6.77) and that in overweight to lean girls was 2.48 (95% CI, 1.05-5.83). Within patients with UTIs, compared with lean children, the obese showed a longer duration of fever and a higher frequency of APN and the overweight had a higher incidence of hydronephrosis (P <.05). Obesity may be associated with higher odds of a febrile UTI and APN in young children.
    Urology 05/2014; · 2.42 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: To evaluate the associations between body mass index (BMI) and prostate volume (PV) and lower urinary tract symptoms in a multiethnic cohort. A cohort of men without prostate cancer seen at our institution was assembled, excluding those with previous transurethral resection of the prostate. Height and weight were measured to compute BMI, PV was measured by transrectal ultrasound, and the International Prostate Symptom Score (IPSS) questionnaire was administered. After stratified bivariate analyses, multiple linear regression and ordinal logistic regression models were used to assess the independent effect of BMI on PV and IPSS, respectively. The cohort included 1613 patients, and mean BMI was 27.1 kg/m(2). Patients with a BMI of <25.0, 25.0-29.9, and 30.0-34.9 had a median PV of 44.0 mL, 48.0 mL, and 52.0 mL, respectively. The African ethnicity subgroup generally had larger median PVs than European and Asian subgroups and had the largest differences in median PV between normal and obese men. There were no significant differences in IPSS or usage of benign prostatic hyperplasia medications between BMI categories. In multivariable analyses, higher BMI was associated with larger PV (P <.001) but not IPSS (P = .91). On the basis of our model, given a PV of 40 mL, 50 mL, and 60 mL, each 5 kg/m(2) increase in BMI was associated with a 2.19 mL, 2.74 mL, and 3.29 mL increase in PV, respectively. Body weight (P <.001) but not height (P = .13) was associated with PV. Higher BMI is associated with larger PV but not worse lower urinary tract symptoms (measured using IPSS). Usage rate of alpha blockers or 5 alpha reductase inhibitors was not significantly different between BMI categories.
    Urology 09/2013; · 2.42 Impact Factor