Article

[Iron therapy: Indications, limitations and modality.]

Service de médecine interne, centre de référence des syndromes drépanocytaires majeurs, université Paris-Descartes, Sorbonne Paris-Cité, hôpital européen Georges-Pompidou, Assistance publique-Hôpitaux de Paris, 20, rue Leblanc, 75908 Paris cedex 15, France; CNRS UMR 8147, 75015 Paris, France; Laboratoire d'excellence du globule rouge (GR-ex), service d'hématologie adulte, université Paris-Descartes, Sorbonne Paris-Cité, hôpital Necker, Assistance publique-Hôpitaux de Paris, 161, rue de Sèvres, 75015 Paris, France.
La Revue de Médecine Interne (Impact Factor: 0.9). 05/2012; DOI: 10.1016/j.revmed.2012.04.007
Source: PubMed

ABSTRACT During the past 10years, the knowledge of iron metabolism has been revolutionized by the discovery of the main regulatory hormone of body iron: hepcidin. Meanwhile, new formulations of intravenous iron have been developed and are already or readily available. In this article, we review the recent pathophysiological mechanisms underlying anemia of chronic disease or due to iron deficiency. We describe the various treatment modalities of iron deficiency anemia using oral or intravenous route and the emerging indications of treatment with iron. Finally, we discuss the situations in which iron supplementation may be harmful.

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