An investigation on vitamin D levels in peripheral blood in rheumatoid arthritis

Department of Rheumatology and Immunology, China-Japan Union Hospital of Jilin University, Changchun 130033, China.
Wei sheng yan jiu = Journal of hygiene research 03/2012; 41(2):313-5.
Source: PubMed


To study the association between vitamin D levels and RA.
Seventy-two postmenopausal female patients with RA (group RA) and fifty-eight healthy volunteers (group control) were included in this study. 25-hydroxyvitamin D3 (25-(OH) D3) levels were determined by ELISA method and disease activity of RA was assessed according to the Disease Activity Score in 28 joints (DAS28). The difference of 25-(OH) D3 levels between two groups and the relationship between 25-(OH) D3 levels and DAS28 were assessed.
25-(OH) D3 levels in peripheral blood in group RA were significantly lower than that in group control (P < 0.05), and 25-(OH)D3 levels were negatively correlated with DAS28.
Vitamin D may have double actions of prevention, treatment and evaluation during the diagnosis and treatment process with RA disease.

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    ABSTRACT: AimTo assess vitamin D levels in rheumatoid arthritis (RA) patients and to find their relation to clinical parameters, fibromyalgia syndrome (FMS), quality of life (QoL) and disease activity.Methods The study included 63 RA patients and 62 controls. Clinical examination and laboratory investigations were performed. For patients, the Disease Activity Score (DAS-28), QoL index, Health Assessment Questionnaire II (HAQ II) and Modified Larsen score were calculated. 25-OH-vitamin D was measured in patients and controls.ResultsThe patients’ mean age was 41.59 ± 9.69 years and disease duration 5.89 ± 3.67 years. The level of vitamin D in RA patients was significantly lower (23.11 ± 12.71 ng/mL) than that in the controls (32.59 ± 13.06 ng/mL) (P = 0.005) being deficient in 50.8%, insufficient in 23.8% and normal in 25.4%. The RA patients with FMS (n = 33) had significantly lower levels of vitamin D (19.08 ± 10.59 ng/mL) than those without (27.55 ± 13.51 ng/mL) (P = 0.008). The difference was significant on comparing those receiving hydroxychloroquine (17.39 ± 7.84 ng/mL) to those not (31.85 ± 13.85 ng/mL) (P < 0.001). Vitamin D significantly correlated with QoL index (r = 0.58, P < 0.001) and negatively with HAQ II (r = −0.36, P = 0.004) and BMI (r = −0.39, P = 0.001).Conclusion Special attention is required regarding vitamin D levels in RA patients with FMS and decreased QoL. Vitamin D should be corrected and supplementation considered among the RA management armamentarium.
    International Journal of Rheumatic Diseases 09/2014; DOI:10.1111/1756-185X.12426 · 1.47 Impact Factor