[Uncomplicated urinary tract infections: impact of increasing antibiotic resistance in the community].
ABSTRACT Uncomplicated urinary tract infections are commonly encountered in primary care and frequently lead to empirical antibiotic prescriptions. The development of antibiotic resistance in the community explains treatment failures observed with commonly-prescribed drugs such as quinolones and co-trimoxazole. This article describes the epidemiology of antibiotic resistance among pathogens causing uncomplicated urinary tract infections and the consequences in terms of recommendations for empirical antibiotic therapy.
- [Show abstract] [Hide abstract]
ABSTRACT: BACKGROUND: Infections of the lower urinary tract and Acute Pyelonephritis are commonly encountered in clinical practice. Widespread usage of antibiotics and changing susceptibility profiles of uropathogens requires regular review of treatment guidelines to meet these challenges. We aimed to better understand the prevalence of uropathogens and emerging antibiotic resistance in patients with pyelonephritis requiring hospital admission. METHODS: In this single centre, 12 year retrospective observational study, we reviewed case notes and urine culture results of 249 patients admitted with Acute Pyelonephritis under the care of the Nephrology Department, along with 46,660 urine samples with positive isolates from the Emergency Department (ED) during the same period. The prevalence of uropathogens, their antibiotic susceptibilities and emerging resistance patterns to commonly used antibiotics were studied. Antibiotic susceptibilities were also reviewed in line with the currently recommended national guidelines for empiric therapy. RESULTS: We found the most prevalent uropathogen to be E. coli. Approximately 50% of E. coli infections were resistant to ampicillin. First and third generation cephalosporin resistance was <5%, however, the latter has increased over the last decade and is more prevalent in the elderly. Enterococcus faecalis was associated with less than 10% of cases of lower urinary tract infections and no case of pyelonephritis. CONCLUSIONS: Antibiotic resistance of uropathogens to commonly used antibiotics is increasing with time and there is a need for hospitals to review their recommended guidelines for empiric therapy in line with local patterns of uropathogens and antibiotic susceptibilities.Nephrology 04/2013; 18(6). DOI:10.1111/nep.12062 · 1.86 Impact Factor