An implanted 8-channel array coil for high-resolution macaque MRI at 3 T
A.A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA.NeuroImage (Impact Factor: 6.36). 05/2012; 62(3):1529-36. DOI: 10.1016/j.neuroimage.2012.05.028
An 8-channel receive coil array was constructed and implanted adjacent to the skull in a male rhesus monkey in order to improve the sensitivity of (functional) brain imaging. The permanent implant was part of an acrylic headpost assembly and only the coil element loop wires were implanted. The tuning, matching, and preamplifier circuitry was connected via a removable external assembly. Signal-to-noise ratio (SNR) and noise amplification for parallel imaging were compared to single-, 4-, and 8-channel external receive-only coils routinely used for macaque fMRI. In vivo measurements showed significantly improved SNR within the brain for the implanted versus the external coils. Within a region-of-interest covering the cerebral cortex, we observed a 5.4-, 3.6-fold, and 3.4-fold increase in SNR compared to the external single-, 4-, and 8-channel coils, respectively. In the center of the brain, the implanted array maintained a 2.4×, 2.5×, and 2.1× higher SNR, respectively compared to the external coils. The array performance was evaluated for anatomical, diffusion tensor and functional brain imaging. This study suggests that a stable implanted phased-array coil can be used in macaque MRI to substantially increase the spatial resolution for anatomical, diffusion tensor, and functional imaging.
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- "We predict that imaging capabilities will continue to improve using, for example, advanced implanted phased array coils (Janssens et al., 2012) or by moving to superhigh-field scanners (>7 T) and different imaging contrasts. Such methodological advances may vastly increase the spatial and temporal resolution of fMRI up to columnar and laminar levels. "
ABSTRACT: We review recent phase-encoded retinotopic mapping data and discuss the spatial relationship between the retinotopically organized monkey cortex and feature- and category-selective clusters. Four areas sharing a foveal representation, V4t, FST, MT, and MSTv, constitute the MT field map cluster. Rostral to V4, areas V4A, OTd, PITv, and PITd also share a foveal representation, again forming a cluster. Concerning the retinotopic organization of face patches, we observed a gradual shift from posterior patches that are retinotopically organized to anterior, nonretinotopic patches. Feature- and category-selective regions in the nonretinotopic IT cortex form repetitive supermodules, each containing face, body, and color patches.12/2015: pages 293-298; Elsevier., ISBN: 9780123973160
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ABSTRACT: Diffusion tensor MRI is sensitive to the coherent structure of brain tissue and is commonly used to study large-scale white matter structure. Diffusion in grey matter is more isotropic, however, several groups have observed coherent patterns of diffusion anisotropy within the cerebral cortical grey matter. We extend the study of cortical diffusion anisotropy by relating it to the local coordinate system of the folded cerebral cortex. We use 1mm and sub-millimeter isotropic resolution diffusion imaging to perform a laminar analysis of the principal diffusion orientation, fractional anisotropy, mean diffusivity and partial volume effects. Data from 6 in vivo human subjects, a fixed human brain specimen and an anesthetized macaque were examined. Large regions of cortex show a radial diffusion orientation. In vivo human and macaque data displayed a sharp transition from radial to tangential diffusion orientation at the border between primary motor and somatosensory cortex, and some evidence of tangential diffusion in secondary somatosensory cortex and primary auditory cortex. Ex vivo diffusion imaging in a human tissue sample showed some tangential diffusion orientation in S1 but mostly radial diffusion orientations in both M1 and S1.NeuroImage 12/2012; 81. DOI:10.1016/j.neuroimage.2012.11.065 · 6.36 Impact Factor
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ABSTRACT: The macaque monkey is an important model for cognitive and sensory neuroscience that has been used extensively in behavioral, electrophysiological, molecular and, more recently, neuroimaging studies. However, macaque MRI has unique technical differences relative to human MRI, such as the geometry of highly parallel receive arrays, which must be addressed to optimize imaging performance. A 22-channel receive coil array was constructed specifically for rapid high-resolution anesthetized macaque monkey MRI at 3 T. A local Helmholtz transmit coil was used for excitation. Signal-to-noise ratios (SNRs) and noise amplification for parallel imaging were compared with those of single- and four-channel receive coils routinely used for macaque MRI. The 22-channel coil yielded significant improvements in SNR throughout the brain. Using this coil, the SNR in peripheral brain was 2.4 and 1.7 times greater than that obtained with single- or four-channel coils, respectively. In the central brain, the SNR gain was 1.5 times that of both the single- and four-channel coils. Finally, the performance of the array for functional, anatomical and diffusion-weighted imaging was evaluated. For all three modalities, the use of the 22-channel array allowed for high-resolution and accelerated image acquisition. Copyright © 2013 John Wiley & Sons, Ltd.NMR in Biomedicine 11/2013; 26(11). DOI:10.1002/nbm.2970 · 3.04 Impact Factor
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