Article

Bringing next-generation therapeutics to the clinic through synthetic biology.

Department of Bioengineering, University of California, Berkeley, Berkeley, CA 94720, USA.
Current opinion in chemical biology (impact factor: 8.3). 05/2012; 16(3-4):355-61. DOI:10.1016/j.cbpa.2012.04.009 pp.355-61
Source: PubMed

ABSTRACT Recent advances in synthetic biology have created genetic tools with the potential to enhance the specificity, dynamic control, efficacy, and safety of medical treatments. Interfacing these genetic devices with human patients may thus bring about more efficient treatments or entirely new solutions to presently intractable maladies. Here we review engineered circuits with clinical potential and discuss their design, implementation, and validation.

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Keywords

clinical potential
 
dynamic control
 
genetic tools
 
human patients
 
new solutions
 
presently intractable maladies
 
Recent advances
 
specificity