Curcumin Inhibits Tongue Carcinoma Cells Migration and Invasion Through Downregulation of Matrix Metallopeptidase 10

Department of Surgery, The University of Hong Kong, SAR China.
Cancer Investigation (Impact Factor: 2.22). 05/2012; 30(7):503-12. DOI: 10.3109/07357907.2012.691192
Source: PubMed


Squamous cell carcinoma (SCC) of tongue is an aggressive head and neck cancer with high propensity of regional spreading and invasion. Tongue carcinoma cells treated with curcumin, the major curcuminoid of the turmeric, demonstrated reduction in adhesion, migration, and invasion ability. High-throughput microarray analysis indicated that curcumin treatment suppressed matrix metallopeptidase 10 (MMP10) expression. MMP10 is overexpressed in tongue carcinoma tissues in comparison with the normal epithelia. Curcumin treatment on tongue carcinoma cell lines suppressed MMP10 expression at both mRNA and protein levels. Our results suggested that curcumin is a promising inhibitor to tongue cancer cells migration and invasion.

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    • "Among other mechanisms of action, cell cycle arrest, induction of apoptosis, regulation of epigenetic events, inhibition of angiogenesis, chemo- and radio-sensitization, have resulted in many preclinical studies and clinical trials. Curcumin's ability to inhibit matrix metalloproteinases, cell migration and invasion [47], [57]–[60] also suggests its potential utility as supplemental treatment to reduce cancer metastasis. In this report, we also provide the first evidence that curcumin induces cellular redistribution of cortactin away from the plasma membrane, induces cortactin dephosphorylation through a direct physical interaction with PTPN1 protein tyrosine phosphatase to increase its activity, and to reduce cancer cell migration. "
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