Intra and extra-hepatic cystadenoma of the biliary duct. Review of literature and radiological and pathological characteristics of a very rare case

Radiology Department, Dalhousie University, Halifax, Canada.
Case Reports 04/2012; 2012. DOI: 10.1136/bcr.01.2012.5497
Source: PubMed


Painless obstructive jaundice is often associated with a malignant disease of the common bile duct or head of the pancreas. The authors present a unique case of a 62-year-old woman affected by an intrahepatic cystadenoma that extended into the common biliary duct. To our knowledge no previous case reports have been published on similar cases. After undergoing an en-block hepatic and bile duct resection, this patient is doing well without signs of recurrent disease.

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    • "Biliary cystadenoma involving the extra- and intrahepatic bile ducts simultaneously is less frequent. To our knowledge, there has been one published case [5] that describes a biliary cystadenoma involving the intrahepatic duct extending to the common bile duct. We aim to highlight here an instance of biliary cystadenoma involving the intra- and extrahepatic bile ducts, which is an uncommon presentation. "
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    ABSTRACT: Biliary cystadenomas are rare tumors of the bile ducts most commonly presenting as large right liver lobe lesions. These are usually slow-growing and mostly benign. They commonly present with abdominal pain. On physical exam an abdominal mass can be identified occasionally. Walls of biliary cystadenomas appear thicker than simple cysts, with soft tissue nodules and enhancing septations on CT or MRI. Radiographic images can vary with the amount of protein content in the fluid on CT or MRI. Due to the risk of malignant transformation, complete surgical resection is advised. Hereby, we describe a 37-year-old lady who presented to the outpatient clinic with bloating and abdominal discomfort with intermittent elevated liver enzymes and hyperbilirubinemia. Ultrasound of the liver and bile ducts followed by CT scan and magnetic resonance cholangiopancreatography confirmed the presence of biliary cystadenoma of the intra- and extrahepatic ducts. It was seen as a filling defect of the intra- and extrahepatic ducts (common hepatic duct) on endoscopic retrograde cholangiopancreatography. Involvement of the intra- and extrahepatic bile ducts simultaneously is a rare presentation of this tumor. She later on underwent exploratory laparotomy with extrahepatic bile duct resection, left hepatic lobe resection and reconstruction with hepaticojejunostomy. Pathology confirmed the presence of biliary cystadenoma with ovarian-like stroma. She had recovered uneventfully from the surgery when seen 2 weeks later in the clinic. Biliary cystadenoma is a rare, mostly benign neoplasm of the biliary tract that should be considered in the differential diagnosis of cystic lesions of the biliary tract.
    Case Reports in Gastroenterology 01/2013; 7(1):7-13. DOI:10.1159/000346297

  • Journal of the American College of Surgeons 09/2013; 218(1). DOI:10.1016/j.jamcollsurg.2013.08.014 · 5.12 Impact Factor
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    ABSTRACT: Background and Objective: salvia officinalis L. consists of, glycosides, flavonoids, and anthocyanins. Due to the increasing use of medicinal plants in treatment of diseases and their side effects on various organs, this study was conducted to evaluate the effect of salvia officinalis on biochemical blood parameters in male rats. Materials and Methods: In this experimental study, 24 male Wistar rats were randomly assigned to four groups of 6 animals each. The control group received normal saline and treatment groups received 75, 150 and 300 mg/kg body weight of salvia extract for 14 days. Body weight was measured in days 0, 7, and 14. At the end of the experiment, serum levels of liver function enzymes such as AST and ALT, total proteins, albumin, creatinine, cholesterol and triglyceride were assessed. Results were analyzed using one-way ANOVA and Tukey test. Results: According to the results, plasma concentrations of protein, albumin and creatinine showed a significant increase (P<0.05) but, a significant decrease was observed in liver enzymes. No significant changes were observed in serum cholesterol, triglyceride levels and body weight in the control and salvia groups (P>0.05). Conclusion: The results indicated that Salvia Officinalis probably contains flavonoidic components with antioxidant effect leading to the increase in albumin and decrease in liver enzymes.
    Journal of Zanjan University of Medical Sciences and Health Services 01/2014; 22(94-94):42-51.
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