Article

Antinociceptive effects of galanin in the nucleus accumbens of rats.

Neurobiology Laboratory and State Key Laboratory of Biomembrane and Membrane Biotechnology, College of Life Sciences, Peking University, Beijing 100871, PR China.
Neuroscience Letters (impact factor: 2.11). 05/2012; 520(1):43-6. DOI:10.1016/j.neulet.2012.05.027 pp.43-6
Source: PubMed

ABSTRACT It has been demonstrated that galanin plays important roles in the modulation of nociceptive information in rats. The present study is performed to investigate the regulating role of galanin in nociception in the nucleus accumbens (NAc) of rats. Intra-NAc administration of galanin induces dose-dependent increases in the hindpaw withdrawal latency (HWL) to noxious thermal and mechanical stimulation in rats. Furthermore, the galanin-induced antinociceptive effects are blocked by following intra-NAc injection of the galanin receptor antagonist galantide. The results demonstrate that galanin induces antinociceptive effects in the NAc of rats, and galanin receptors are involved in the galanin-induced antinociception effects.

0 0
 · 
0 Bookmarks
 · 
56 Views
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.

Keywords

galanin induces antinociceptive effects
 
galanin induces dose-dependent increases
 
galanin receptor antagonist galantide
 
galanin-induced antinociception effects
 
galanin-induced antinociceptive effects
 
hindpaw withdrawal latency
 
intra-NAc injection
 
mechanical stimulation
 
nociceptive information
 
rats
 
regulating role
 
roles
 

Shi-Lian Xu