Article

IRView: a database and viewer for protein interacting regions.

Division of Interactome Medical Sciences, Institute of Medical Science, The University of Tokyo, Tokyo 108-8039, Japan.
Bioinformatics (Impact Factor: 5.47). 05/2012; 28(14):1949-50. DOI: 10.1093/bioinformatics/bts289
Source: PubMed

ABSTRACT Protein-protein interactions (PPIs) are mediated through specific regions on proteins. Some proteins have two or more protein interacting regions (IRs) and some IRs are competitively used for interactions with different proteins. IRView currently contains data for 3417 IRs in human and mouse proteins. The data were obtained from different sources and combined with annotated region data from InterPro. Information on non-synonymous single nucleotide polymorphism sites and variable regions owing to alternative mRNA splicing is also included. The IRView web interface displays all IR data, including user-uploaded data, on reference sequences so that the positional relationship between IRs can be easily understood. IRView should be useful for analyzing underlying relationships between the proteins behind the PPI networks. AVAILABILITY: IRView is publicly available on the web at http://ir.hgc.jp/

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