Nationwide surveillance study of human astrovirus infections in an Italian paediatric population.
ABSTRACT The study investigated the genetic diversity of human astroviruses (HAstVs) detected in children hospitalized with gastroenteritis in Italy in 2008-2009. A total of 1321 faecal samples were collected in Parma (northern Italy), Bari (southern Italy), and Palermo (Sicily) and screened for the presence of HAstVs. RT-PCR amplification of a portion at the 5'-end of ORF2 allowed the detection of HAstVs in 3·95% of the patients. Four different genotypes (HAstV-1, HAstV-2, HAstV-4, HAstV-5) were found to be circulating during the study period, with HAstV-1 being the predominant type. Interestingly, a novel lineage, proposed as HAstV-2d, was found to have emerged in Parma in 2009. Investigating the genetic variability of HAstVs will be important for understanding the epidemiological trends and evolution of these viruses.
Molecular epidemiology of astrovirus infection in Barcelona, Spain. Journal of Clinical Microbiology 40 133-139..
Age-stratified seroprevalence of neutralizing antibodies to astrovirus types 1 to 7 in humans in The Netherlands 4 S. De Grazia and others 3. Bayai K, et al. Detection of newly described astrovirus MLB1 in stool samples from children. Clinical and Diagnostic Laboratory Immunology Emerging Infectious Diseases 5 33-37..
Epidemiology of astrovirus infection in young children hospitalized with acute gastroenteritis in Melbourn, Australia, over a period of four consecutive years. Journal of Clinical Microbiology 38 1058-1062..