Article

High-density lipoprotein subclass and particle size in coronary heart disease patients with or without diabetes.

Laboratory of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, People's Republic of China. .
Lipids in Health and Disease (impact factor: 2.17). 05/2012; 11:54. DOI:10.1186/1476-511X-11-54 pp.54
Source: PubMed

ABSTRACT A higher prevalence of coronary heart disease (CHD) in people with diabetes. We investigated the high-density lipoprotein (HDL) subclass profiles and alterations of particle size in CHD patients with diabetes or without diabetes.
Plasma HDL subclasses were quantified in CHD by 1-dimensional gel electrophoresis coupled with immunodetection.
Although the particle size of HDL tend to small, the mean levels of low density lipoprotein cholesterol(LDL-C) and total cholesterol (TC) have achieved normal or desirable for CHD patients with or without diabetes who administered statins therapy. Fasting plasma glucose (FPG), triglyceride (TG), TC, LDL-C concentrations, and HDL3 (HDL3b and 3a) contents along with Gensini Score were significantly higher; but those of HDL-C, HDL2b+preβ2, and HDL2a were significantly lower in CHD patients with diabetes versus CHD patients without diabetes; The preβ1-HDL contents did not differ significantly between these groups. Multivariate regression analysis revealed that Gensini Score was significantly and independently predicted by HDL2a, and HDL2b+preβ2.
The abnormality of HDL subpopulations distribution and particle size may contribute to CHD risk in diabetes patients. The HDL subclasses distribution may help in severity of coronary artery and risk stratification, especially in CHD patients with therapeutic LDL, TG and HDL levels.

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Keywords

1-dimensional gel electrophoresis
 
CHD patients
 
CHD risk
 
coronary artery
 
coronary heart disease
 
diabetes patients
 
Fasting plasma glucose
 
HDL levels
 
HDL subclasses distribution
 
HDL subpopulations distribution
 
HDL2a
 
HDL3b
 
high-density lipoprotein
 
low density lipoprotein cholesterol(LDL-C)
 
mean levels
 
Multivariate regression analysis
 
Plasma HDL subclasses
 
preβ1-HDL contents
 
risk stratification
 
total cholesterol