DNA origami metallized site specifically to form electrically conductive nanowires.
ABSTRACT DNA origami is a promising tool for use as a template in the design and fabrication of nanoscale structures. The ability to engineer selected staple strands on a DNA origami structure provides a high density of addressable locations across the structure. Here we report a method using site-specific attachment of gold nanoparticles to modified staple strands and subsequent metallization to fabricate conductive wires from DNA origami templates. We have modified DNA origami structures by lengthening each staple strand in select regions with a 10-base nucleotide sequence and have attached DNA-modified gold nanoparticles to the lengthened staple strands via complementary base-pairing. The high density of extended staple strands allowed the gold nanoparticles to pack tightly in the modified regions of the DNA origami, where the measured median gap size between neighboring particles was 4.1 nm. Gold metallization processes were optimized so that the attached gold nanoparticles grew until gaps between particles were filled and uniform continuous nanowires were formed. Finally, electron beam lithography was used to pattern electrodes in order to measure the electrical conductivity of metallized DNA origami, which showed an average resistance of 2.4 kΩ per metallized structure.
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ABSTRACT: Controlling matter at the nanoscale holds a lot of promise in nanotechnology. The DNA origami is promising if used as a template to design and arrange matter at the nanoscale. We have used the DNA origami approach to engineer staple strands at selected sites for attachment of gold nanoparticles. The covalent attachment of thiol-modified DNA oligomers was used to functionalize gold nanoparticles. These oligomers then hybridize with complementary strands extended on selected staple strands on the DNA origami surface with nanometer precision. Gold nanoparticles of 5 nm diameter were arranged across a DNA origami tube to form a C-shape which has potential use in electronics and plasmonics. Agarose gel electrophoresis, AFM, UV-Vis spectroscopy and TEM were used to characterize the structure.Nano brief reports and reviews 11/2013; 08(06). · 1.26 Impact Factor
- Chemistry of Materials 09/2014; 26(18):5265-5273. · 8.54 Impact Factor
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ABSTRACT: Self-assembled DNA-templated structures have been an area of active development over recent years. They provide a cheaper, more practical bottom-up approach for producing nano-structures compared to current industry standards. This review focuses on recent developments in this field. Methods of synthesis are covered including the DNA templates used, how they are aligned, and the self-assembly approaches taken. Characterisation is discussed including various imaging techniques and the electronic and optical properties that these structures possess. A broad range of applications are described including conductive nanowires, biosensors and thin film photonics.Journal of Materials Chemistry C 01/2014; 2(34-34):6895-6920.