Article

Long working hours and cardiovascular disease: a meta-analysis of epidemiologic studies.

Department of Preventive Medicine, College of Medicine, Seoul National University, Seoul, Republic of Korea.
Journal of occupational and environmental medicine / American College of Occupational and Environmental Medicine (impact factor: 1.88). 05/2012; 54(5):532-7. DOI:10.1097/JOM.0b013e31824fe192 pp.532-7
Source: PubMed

ABSTRACT To conduct a meta-analysis from published studies to evaluate the relationship between long working hours and the risk of cardiovascular disease (CVD).
Among a total of 341 published studies found from publicly accessible databases, five cohort studies and six case-control studies were analyzed for the study.
Statistically significant heterogeneity has been observed (P = 0.037). The effect of longer working hours was significantly associated with the risk of CVD in the random-effects model of all 11 studies (odds ratio, 1.37; 95% confidence interval, 1.11 to 1.70). On the basis of meta-regression analysis, the result was not affected by the mean age, region, or the study year. The P value using Eager test was 0.701 suggesting this analysis was unlikely to have any publication bias.
These findings provide evidence of increased CVD with long working hours.

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Keywords

11 studies
 
95% confidence interval
 
accessible databases
 
cardiovascular disease
 
case-control studies
 
CVD
 
Eager test
 
meta-analysis
 
meta-regression analysis
 
P value
 
publication bias
 
random-effects model
 
Statistically significant heterogeneity
 

Mo-Yeol Kang