Genome sequence of herpes simplex virus 1 strain KOS.

Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas, USA.
Journal of Virology (Impact Factor: 5.08). 06/2012; 86(11):6371-2. DOI: 10.1128/JVI.00646-12
Source: PubMed

ABSTRACT Herpes simplex virus type 1 (HSV-1) strain KOS has been extensively used in many studies to examine HSV-1 replication, gene expression, and pathogenesis. Notably, strain KOS is known to be less pathogenic than the first sequenced genome of HSV-1, strain 17. To understand the genotypic differences between KOS and other phenotypically distinct strains of HSV-1, we sequenced the viral genome of strain KOS. When comparing strain KOS to strain 17, there are at least 1,024 small nucleotide polymorphisms (SNPs) and 172 insertions/deletions (indels). The polymorphisms observed in the KOS genome will likely provide insights into the genes, their protein products, and the cis elements that regulate the biology of this HSV-1 strain.

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