Article

The myosin superfamily at a glance

Department of Biochemistry, Stanford University, Stanford, CA 94305, USA.
Journal of Cell Science (Impact Factor: 5.33). 04/2012; 125(Pt 7):1627-32. DOI: 10.1242/jcs.094300
Source: PubMed
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    • "Myosin Superfamily M yosins are actin-dependent molecular motors that utilize the energy of ATP hydrolysis to generate force. The many functions of myosins include cell contractility, cell signaling, endocytosis, vesicle trafficking and protein/ RNA localization [Krendel and Mooseker, 2005; Woolner and Bement, 2009; Hartman and Spudich, 2012]. All myosins share certain structural and functional features, particularly the presence of an actin-binding head domain, which is also responsible for myosin ATPase activity. "
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    • "Myosins participate in a variety of cellular processes, including cytokinesis , organellar transport, cell polarization, transcriptional regulation, intracellular transport, and signal transduction (Hofmann et al. 2009; Bloemink and Geeves 2011; Hartman et al. 2011). They bind to filamentous actin and produce physical forces by hydrolyzing ATP and converting chemical energy into mechanical force (Hartman and Spudich 2012). Both activities reside in the myosin head domain (PF00063). "
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