Article

The antiproteinuric effects of green tea extract on acute cyclosporine-induced nephrotoxicity in rats.

Department of Internal Medicine, Division of Nephrology, Chosun University Hospital, Gwangju, Republic of Korea.
Transplantation Proceedings (impact factor: 1). 05/2012; 44(4):1080-2. DOI:10.1016/j.transproceed.2012.03.047 pp.1080-2
Source: PubMed

ABSTRACT It has been reported that the proteinuria is an early useful marker to detect cyclosporine (CsA) nephrotoxicity. The aim of this study was to investigate the antiproteinuric effects of green tea extract (GTE) on CsA-induced acute renal injury in rats.
The rats (n = 28) were divided into four groups (n = 7/group); controls intraperitoneally (IP) injected with 0.9% saline; CsA group IP injected CsA (50 mg/kg); inducible nitric oxide synthase (iNOS) inhibitor group administered in addition NG-nitro-L-arginine-methyl ester (12 mmol/L) subcutaneously and CsA-GTE group of CsA IP plus GTE (100 mg/kg) subcutaneously.
The 24-hour urine proteins were significantly increased among the CsA (22.6 ± 3.1 mg/d) compared with the control (7.1 ± 1.5 mg/d) and significantly decreased in the CsA-GTE group (8.2 ± 1.8 mg/d, P < .01). Nitric oxide production induces by CsA treatment was significantly suppressed by GTE and iNOS inhibitor. Renal tissue malondialdehyde level was significantly increased in the CsA compared with controls and significantly decreased in the CsA-GTE group. The antioxidant enzyme activities of superoxide dysmutase and catalase, which were significantly suppressed in the CsA compared with the control group, were restored in the CsA-GTE cohort.
GTE treatment of rats showed meaningful antiproteinuric effects through antioxidative activity in kidneys from CsA-induced acute renal injury.

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Keywords

24-hour urine proteins
 
antioxidant enzyme activities
 
antiproteinuric effects
 
control group
 
controls intraperitoneally
 
CsA
 
CsA group IP
 
CsA IP
 
CsA treatment
 
CsA-GTE cohort
 
CsA-GTE group
 
CsA-induced acute renal injury
 
GTE treatment
 
inducible nitric oxide synthase
 
iNOS inhibitor
 
meaningful antiproteinuric effects
 
NG-nitro-L-arginine-methyl ester
 
Renal tissue malondialdehyde level
 
superoxide dysmutase
 
useful marker
 

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