Rapid diagnostic tests for a coordinated approach to fever syndromes in low-resource settings.

Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.
Clinical Infectious Diseases (Impact Factor: 9.42). 05/2012; 55(4):610-1; author reply 611-2. DOI: 10.1093/cid/cis466
Source: PubMed
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Microscopy has several limitations in the diagnosis of parasitic infection. New technologies have emerged to address some of these limitations. We review recent advances in three key areas. The detection of enteric protozoa is a commonly requested test, particularly with increasing travel to and migration from endemic countries. Microscopy is slow and labor intensive and requires a high level of technical expertise. It also lacks both sensitivity and specificity. Recently developed nucleic acid amplification tests are automated and rapid and show superior accuracy. Proteomics shows promise for both the diagnosis of infections where parasite detection is difficult and the potential for accurate assessment of cure in these cases. Finally, rapid and simple diagnostic tests suitable for use in low-resource settings are now allowing for improved study and control of infection in endemic regions.
    Current Infectious Disease Reports 11/2014; 16(11):434. DOI:10.1007/s11908-014-0434-9
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Severe malaria is a medical emergency requiring early intervention to prevent death. This article highlights key aspects of the management of severe malaria syndromes in the intensive care unit, with a focus on individual case management of imported malaria. Key differences in the presentation, management, and outcomes of severe malaria by endemicity and by age group are emphasized. In all groups with severe malaria, intravenous artesunate is the antimalarial agent of choice. This article discusses specific antimalarial therapies, optimal supportive management strategies, differences from strategies for bacterial sepsis, and trials of adjunctive therapy for severe malaria in humans.
    Critical care clinics 10/2013; 29(4):865-885. DOI:10.1016/j.ccc.2013.06.008 · 1.72 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: We describe the first case of bacteraemia caused by Chromobacterium violaceum in the Democratic Republic of the Congo. This diagnosis was made in an apparently healthy adult who was admitted to a rural hospital of the province of Bandundu with severe community-acquired sepsis. The patient developed multi-organ failure and died; to our knowledge, this is the first reported fatal case in an adult in Africa.
    01/2015; 3:21-23. DOI:10.1016/j.nmni.2014.10.007


Available from
May 20, 2014