Article

Lipoproteins of Actinomyces viscosus induce inflammatory responses through TLR2 in human gingival epithelial cells and macrophages.

Department of Oral Microbiology, Showa University School of Dentistry, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan.
Microbes and Infection (impact factor: 3.1). 05/2012; 14(11):916-21. DOI:10.1016/j.micinf.2012.04.015 pp.916-21
Source: PubMed

ABSTRACT Actinomyces viscosus has been suggested to be associated with periodontal disease. However, the pathogenicity of this bacterium is not known. In this study, we examined inflammation-inducing activity by A. viscosus. Whole cells and a lipophilic fraction of A. viscosus ATCC19246 induced production of interleukin-8 and tumor necrosis factor alpha from both human oral epithelial cells and human monocytoid cells. This cytokine production was blocked by lipoprotein lipase treatment of the lipophilic fraction. In addition, anti-Toll-like receptor 2 antibody blocked the cytokine production. These results suggest that lipoprotein of A. viscosus triggers inflammatory responses in periodontitis by activation of Toll-like receptor 2.

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Keywords

A. viscosus
 
A. viscosus ATCC19246 induced production
 
A. viscosus triggers inflammatory responses
 
anti-Toll-like receptor 2 antibody
 
cytokine production
 
human monocytoid cells
 
human oral epithelial cells
 
inflammation-inducing activity
 
lipophilic fraction
 
lipoprotein lipase treatment
 
periodontal disease
 
tumor necrosis factor alpha
 
Whole cells
 

Eri Shimada