Article

[Serum retinol binding protein 4 and bone metabolism in patients with type 2 diabetes].

Institute of Metabolism and Endocrinology, Second Xiangya Hospital, Central South University, Changsha, China.
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 02/2012; 37(2):197-202. DOI:10.3969/j.issn.1672-7347.2012.02.015
Source: PubMed

ABSTRACT To determine the relation between serum concentration of retinol binding protein (RBP) 4 and markers of bone metabolism, bone mineral density (BMD) in patients with type 2 diabetes mellitus (T2DM).
A total of 82 patients newly diagnosed with T2DM and 46 subjects with normal glucose tolerance (NGT) enrolled in the cross-sectional study. Subset analyses were performed, dividing subjects on the basis of gender into M-T2DM, F-T2DM, M-NGT, and F-NGT. The serum concentrions of RBP4, osteocalcin (OC) and C-terminal telopeptide of collagen type I (CTX) were measured with ELISA. The BMD was measured by dual-energy X-ray absorptiometry (DXA) with a Hologic QDR4500A device.
In both the T2DM groups, lnRBP4 showed a positive relationship with lnCTX (M-T2DM, r=0.564, P<0.01; F-T2DM, r=0.386, P=0.018), but no association with lnOC. After adjusting for age, smoking, creatinine clearance rate (CCr), and waist-to-hip ratio (WHR), lnRBP4 still showed a strong association with lnCTX in the M-T2DM group (r'=0.536, P<0.01), but not in F-T2DM (r'=0.317, P=0.072). In the NGT group, there was no relation between lnRBP4 and lnCTX or lnOC. LnRBP4 showed no association with BMD in all groups.
The level of serum RBP4 may be correlated with the bone metabolism in patients with T2DM.

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Keywords

46 subjects
 
82 patients
 
bone metabolism
 
bone mineral density
 
collagen type
 
creatinine clearance rate
 
cross-sectional study
 
dual-energy X-ray absorptiometry
 
Hologic QDR4500A device
 
M-T2DM
 
M-T2DM group
 
normal glucose tolerance
 
positive relationship
 
retinol binding protein
 
serum concentrions
 
strong association
 
Subset analyses
 
T2DM groups
 
type 2 diabetes mellitus
 
waist-to-hip ratio