Article

Muscling in on PGC-1α for improved quality of life in ALS.

Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York-Presbyterian Hospital, New York, NY 10065, USA.
Cell metabolism (impact factor: 17.35). 05/2012; 15(5):567-9. DOI:10.1016/j.cmet.2012.04.015 pp.567-9
Source: PubMed

ABSTRACT Impaired activity of peroxisome proliferator-activated receptor (PPAR)-γ coactivator (PGC)-1α has been implicated in the pathophysiology of several neurodegenerative disorders. In this issue, Da Cruz et al. (2012) show improved muscle function, but not survival, with increased PGC-1α activity in muscle in a mouse model of amyotrophic lateral sclerosis.

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Keywords

Da Cruz
 
mouse model
 
muscle function
 
neurodegenerative disorders
 
pathophysiology
 
peroxisome proliferator-activated receptor