Article

NuRD and pluripotency: a complex balancing act.

Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.
Cell stem cell (Impact Factor: 23.56). 05/2012; 10(5):497-503. DOI: 10.1016/j.stem.2012.04.011
Source: PubMed

ABSTRACT Embryonic stem cells (ESCs) are defined by two essential features--pluripotency and self-renewal--whose balance requires the concerted action of signal transduction pathways, transcription factor networks, and epigenetic regulators. Recent findings have implicated the NuRD chromatin remodeling complex in the sophisticated choreography of ESC regulatory pathways.

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