PSA Lo and behold: Prostate cancer stem cells

University of Michigan Comprehensive Cancer Center, Ann Arbor, MI 48109-5942, USA.
Cell stem cell (Impact Factor: 22.27). 05/2012; 10(5):482-3. DOI: 10.1016/j.stem.2012.04.014
Source: PubMed

ABSTRACT Human prostate cancers contain multiple cell populations marked by varying levels of the differentiation marker prostate-specific antigen (PSA). In this issue of Cell Stem Cell, Qin et al. (2012) show that PSA(-/lo) cells are enriched for cells with tumor-initiating characteristics and may participate in resistance to androgen-ablative therapies.

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