Thioether Crosslinkages Created by a Radical SAM Enzyme

Key Laboratory of Combinatory Biosynthesis and Drug Discovery (Ministry of Education) and School of Pharmaceutical Sciences, Wuhan University, 185 East Lake Road, Wuhan 430071, PR China.
ChemBioChem (Impact Factor: 3.09). 05/2012; 13(8):1097-9. DOI: 10.1002/cbic.201200196
Source: PubMed


Unusually versatile: While the β-carbon thioether linkage in lantibiotics has long been appreciated and is relatively well characterized, a recent publication shows that the unusual sulfur-to-α-carbon thioether crosslinks in subtilosin A are produced by a radical SAM enzyme, AlbA, that contains two [4 Fe-4 S] clusters, thus highlighting the versatility of post-translational modifications in natural product biosynthesis.

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