Article

Thioether crosslinkages created by a radical SAM enzyme.

Key Laboratory of Combinatory Biosynthesis and Drug Discovery (Ministry of Education) and School of Pharmaceutical Sciences, Wuhan University, 185 East Lake Road, Wuhan 430071, PR China.
ChemBioChem (impact factor: 3.94). 05/2012; 13(8):1097-9. DOI:10.1002/cbic.201200196 pp.1097-9
Source: PubMed

ABSTRACT Unusually versatile: While the β-carbon thioether linkage in lantibiotics has long been appreciated and is relatively well characterized, a recent publication shows that the unusual sulfur-to-α-carbon thioether crosslinks in subtilosin A are produced by a radical SAM enzyme, AlbA, that contains two [4 Fe-4 S] clusters, thus highlighting the versatility of post-translational modifications in natural product biosynthesis.

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Keywords

AlbA
 
lantibiotics
 
recent publication
 
unusual sulfur-to-α-carbon thioether crosslinks
 
versatility
 
β-carbon thioether linkage
 

Qi Zhang