Article

Off-targeting oft-targeted CD20 in cHL.

Robert H. Lurie Comprehensive Cancer Center.
Blood (Impact Factor: 9.78). 05/2012; 119(18):4095-6. DOI: 10.1182/blood-2012-03-413146
Source: PubMed

ABSTRACT We now think of classical Hodgkin lymphoma (cHL) as derived from "crippled" germinal center B cells that have frequently acquired rearranged and somatically mutated Ig genes.1,2 Despite their B-cell origin, the malignant Hodgkin and Reed-Sternberg (HRS) cells have lost most of the superficial trappings of B cells and therefore have been hidden from investigators' lenses for decades, prompting an arduous but persistent race to uncover the mystery of the HRS cell.

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